Matches in SemOpenAlex for { <https://semopenalex.org/work/W2870640276> ?p ?o ?g. }
- W2870640276 endingPage "1138" @default.
- W2870640276 startingPage "1127" @default.
- W2870640276 abstract "Pigment epithelium-derived factor (PEDF), a multifunctional endogenous glycoprotein, has a very wide range of biological actions, notably in bone homeostasis. The question has been raised regarding the place of PEDF in the treatment of bone disorders and osteosarcoma, and its potential for tumour growth suppression.The PubMed database was used to compile this review.Pigment epithelium-derived factor's actions in osteoid tissues include promoting mesenchymal stem cell commitment to osteoblasts, increasing matrix mineralisation, and promoting osteoblast proliferation. It shows potential to improve therapeutic outcomes in treatment of multiple cancer types and regrowth of bone after trauma or resection in animal studies. PEDF may possibly have a reduced adverse effect profile compared with current osteo-regenerative treatments; however, there is currently very limited evidence regarding the safety or efficacy in human models.Pigment epithelium-derived factor is very active within the body, particularly in osseous tissue, and its physiological actions give it potential for treatment of both bone disorders and multiple tumour types. Further research is needed to ascertain the adverse effects and safety profile of PEDF as a therapeutic agent." @default.
- W2870640276 created "2018-07-19" @default.
- W2870640276 creator A5057418546 @default.
- W2870640276 creator A5073647764 @default.
- W2870640276 date "2018-07-05" @default.
- W2870640276 modified "2023-09-26" @default.
- W2870640276 title "Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy" @default.
- W2870640276 cites W1537898230 @default.
- W2870640276 cites W1578532631 @default.
- W2870640276 cites W1628083287 @default.
- W2870640276 cites W1963773424 @default.
- W2870640276 cites W1964110651 @default.
- W2870640276 cites W1965788588 @default.
- W2870640276 cites W1969005256 @default.
- W2870640276 cites W1973730898 @default.
- W2870640276 cites W1976528923 @default.
- W2870640276 cites W1977389640 @default.
- W2870640276 cites W1982265214 @default.
- W2870640276 cites W1985091677 @default.
- W2870640276 cites W1987004605 @default.
- W2870640276 cites W1989180224 @default.
- W2870640276 cites W1992866776 @default.
- W2870640276 cites W2002268391 @default.
- W2870640276 cites W2005381157 @default.
- W2870640276 cites W2007691284 @default.
- W2870640276 cites W2014208932 @default.
- W2870640276 cites W2016051392 @default.
- W2870640276 cites W2019336811 @default.
- W2870640276 cites W2020205659 @default.
- W2870640276 cites W2026011922 @default.
- W2870640276 cites W2028945872 @default.
- W2870640276 cites W2030544273 @default.
- W2870640276 cites W2040605943 @default.
- W2870640276 cites W2043004414 @default.
- W2870640276 cites W2043609102 @default.
- W2870640276 cites W2048126892 @default.
- W2870640276 cites W2048884644 @default.
- W2870640276 cites W2050236400 @default.
- W2870640276 cites W2052774003 @default.
- W2870640276 cites W2053288021 @default.
- W2870640276 cites W2054043643 @default.
- W2870640276 cites W2056089881 @default.
- W2870640276 cites W2056301653 @default.
- W2870640276 cites W2058697506 @default.
- W2870640276 cites W2061984686 @default.
- W2870640276 cites W2062558205 @default.
- W2870640276 cites W2064347506 @default.
- W2870640276 cites W2065533441 @default.
- W2870640276 cites W2066905784 @default.
- W2870640276 cites W2066968550 @default.
- W2870640276 cites W2070173087 @default.
- W2870640276 cites W2073758242 @default.
- W2870640276 cites W2077202113 @default.
- W2870640276 cites W2081026839 @default.
- W2870640276 cites W2081141453 @default.
- W2870640276 cites W2083698829 @default.
- W2870640276 cites W2083903421 @default.
- W2870640276 cites W2084874657 @default.
- W2870640276 cites W2085217504 @default.
- W2870640276 cites W2086418547 @default.
- W2870640276 cites W2086763458 @default.
- W2870640276 cites W2090594937 @default.
- W2870640276 cites W2091524320 @default.
- W2870640276 cites W2093641379 @default.
- W2870640276 cites W2098942350 @default.
- W2870640276 cites W2099793701 @default.
- W2870640276 cites W2105054202 @default.
- W2870640276 cites W2110146900 @default.
- W2870640276 cites W2119443210 @default.
- W2870640276 cites W2119626954 @default.
- W2870640276 cites W2119962765 @default.
- W2870640276 cites W2125857619 @default.
- W2870640276 cites W2128261464 @default.
- W2870640276 cites W2130434621 @default.
- W2870640276 cites W2132063659 @default.
- W2870640276 cites W2135944410 @default.
- W2870640276 cites W2138091232 @default.
- W2870640276 cites W2139001910 @default.
- W2870640276 cites W2140907695 @default.
- W2870640276 cites W2144023435 @default.
- W2870640276 cites W2146895939 @default.
- W2870640276 cites W2148713009 @default.
- W2870640276 cites W2156063893 @default.
- W2870640276 cites W2158135268 @default.
- W2870640276 cites W2158773155 @default.
- W2870640276 cites W2159466155 @default.
- W2870640276 cites W2159856988 @default.
- W2870640276 cites W2167081905 @default.
- W2870640276 cites W2170402173 @default.
- W2870640276 cites W2182832651 @default.
- W2870640276 cites W2183640445 @default.
- W2870640276 cites W2225056950 @default.
- W2870640276 cites W2316214239 @default.
- W2870640276 cites W2342506999 @default.
- W2870640276 cites W2399717014 @default.
- W2870640276 cites W2510126611 @default.
- W2870640276 cites W2516945870 @default.
- W2870640276 cites W2605708780 @default.