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- W287064857 abstract "Female iron-deficient (ID) rats have plasma triiodothyronine (T{sub 3}) concentrations similar to iron sufficient controls (CN) at 24C. Whether the apparently euthyroid ID female can thermoregulate when exposed to cold was studied to assess the interactive effects of iron deficiency and the female reproductive cycle. Rats were assigned to either ID (n = 60) or CN (n = 60) diets for a period of five weeks. The two groups were then subdivided into five groups, four based on stage of the estrous cycle and the fifth group was ovariectomized one week prior to sacrifice. Animals were exposed to 4C for 6 h. Following sacrifice, tissues were collected for analysis of thyroid hormone and iron status indices. There was an interactive effect of iron status and the estrous cycle on core temperature response to the cold. Plasma thyrozine (T{sup 4}) concentrations were unaffected by iron status or the estrous cycle, and plasma T{sub 3} concentrations were significantly lower in ID than CN rats. Thyroxine 5{prime} - deiodinase activity in the liver was significantly lower in ID animals than CN; this conforms with the plasma T{sub 3} findings. Brown adipose tissue deiodinase was not affected by either iron status or the estrousmore » cycle. In conclusion, iron deficiency impairs thermoregulation in rats, and this effect is related to the ovarian cycle. However, brown adipose tissue does not appear specifically involved in this defect.« less" @default.
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- W287064857 date "1991-03-11" @default.
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- W287064857 title "Estrous cycle and cold stress in iron-deficient rats" @default.
- W287064857 hasPublicationYear "1991" @default.
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