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- W287068954 abstract "Publisher Summary This chapter discusses stimulation of lymphocytes with Antibodies to surface membrane-bound antigen receptors. B lymphocytes express surface membrane-bound Ig (mlg) that serves as a clonally expressed receptor for antigen, thereby determining the specificity of a humoral immune response. Since the demonstration that rabbit lymphocytes proliferate after exposure to antibodies to allotypic Ig determinants, many investigators have used anti-Ig preparations to activate multiple B lymphocytes, in a manner that presumably mimics antigen binding to the mlg receptor. Because most B cells express IgM, antibodies to the IgM molecule have been used most frequently for these purposes. However, it would appear that under suitable culture conditions, appropriately prepared anti-Ig antibody preparations reactive with IgG, A, D heavy chains, and kappa or lambda light-chain determinants (as well as to IgM) may induce proliferation of B cells displaying the corresponding isotype. Therefore, a selected or broad range of mlg-expressing B cells can be activated by means of the specificity of the anti-Ig used." @default.
- W287068954 created "2016-06-24" @default.
- W287068954 creator A5040500242 @default.
- W287068954 date "1987-01-01" @default.
- W287068954 modified "2023-10-18" @default.
- W287068954 title "Stimulation of lymphocytes with antibodies to surface membrane-bound antigen receptors" @default.
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- W287068954 doi "https://doi.org/10.1016/0076-6879(87)50068-4" @default.
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- W287068954 hasPublicationYear "1987" @default.
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