Matches in SemOpenAlex for { <https://semopenalex.org/work/W287168328> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W287168328 endingPage "308b" @default.
- W287168328 startingPage "308b" @default.
- W287168328 abstract "Lymphopenia results in the homeostatic peripheral expansion of lymphocytes to maintain T cell homeostasis. Accumulating data show that lymphopenia-induced proliferation (LIP) has a pathogenic role in the development of autoimmunity in animal models and human systemic autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome and rheumatoid arthritis. To clarify the mechanism of anti-nuclear antibodies (ANA) production, we established a lymphopenic mouse model in which CD4+ T cell subsets from wild-type BALB/c mice were adoptively injected into BALB/c nude mice, which induced IgG-type ANA production. We observed that class switching and ANA production were enhanced when regulatory T cells were depleted. We identified IL-21-producing PD-1+ TFH cells which develop from conventional T cells during LIP and drive germinal center reactions with aberrant B cell responses. Compared with traditional TFH cells, this subset has a distinctive ontogeny and a critical role in breaking B cell tolerance. This study reveals the physiological mechanism how immunological tolerance is maintained during LIP and would help to understand the pathogenesis of systemic autoimmune diseases." @default.
- W287168328 created "2016-06-24" @default.
- W287168328 date "2012-01-01" @default.
- W287168328 modified "2023-09-25" @default.
- W287168328 title "W5-2 Lymphopenia-induced proliferation (LIP) triggers the development of follicular helper T (T<sub>FH</sub>) cells which have a distinctive ontogeny and a critical role in aberrant B cell responses" @default.
- W287168328 doi "https://doi.org/10.2177/jsci.35.308b" @default.
- W287168328 hasPublicationYear "2012" @default.
- W287168328 type Work @default.
- W287168328 sameAs 287168328 @default.
- W287168328 citedByCount "0" @default.
- W287168328 crossrefType "journal-article" @default.
- W287168328 hasBestOaLocation W2871683281 @default.
- W287168328 hasConcept C159654299 @default.
- W287168328 hasConcept C203014093 @default.
- W287168328 hasConcept C2776090121 @default.
- W287168328 hasConcept C2777016536 @default.
- W287168328 hasConcept C2778453870 @default.
- W287168328 hasConcept C2780130043 @default.
- W287168328 hasConcept C86803240 @default.
- W287168328 hasConcept C8891405 @default.
- W287168328 hasConcept C95444343 @default.
- W287168328 hasConcept C96926380 @default.
- W287168328 hasConceptScore W287168328C159654299 @default.
- W287168328 hasConceptScore W287168328C203014093 @default.
- W287168328 hasConceptScore W287168328C2776090121 @default.
- W287168328 hasConceptScore W287168328C2777016536 @default.
- W287168328 hasConceptScore W287168328C2778453870 @default.
- W287168328 hasConceptScore W287168328C2780130043 @default.
- W287168328 hasConceptScore W287168328C86803240 @default.
- W287168328 hasConceptScore W287168328C8891405 @default.
- W287168328 hasConceptScore W287168328C95444343 @default.
- W287168328 hasConceptScore W287168328C96926380 @default.
- W287168328 hasIssue "4" @default.
- W287168328 hasLocation W2871683281 @default.
- W287168328 hasOpenAccess W287168328 @default.
- W287168328 hasPrimaryLocation W2871683281 @default.
- W287168328 hasRelatedWork W2029140584 @default.
- W287168328 hasRelatedWork W2029657220 @default.
- W287168328 hasRelatedWork W2029907583 @default.
- W287168328 hasRelatedWork W2102693678 @default.
- W287168328 hasRelatedWork W2518196601 @default.
- W287168328 hasRelatedWork W2593968410 @default.
- W287168328 hasRelatedWork W3171317471 @default.
- W287168328 hasRelatedWork W4220949599 @default.
- W287168328 hasRelatedWork W4313358925 @default.
- W287168328 hasRelatedWork W4367186593 @default.
- W287168328 hasVolume "35" @default.
- W287168328 isParatext "false" @default.
- W287168328 isRetracted "false" @default.
- W287168328 magId "287168328" @default.
- W287168328 workType "article" @default.