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• W287343231 abstract "Fish oil rich in docosahexaenoic acid (DHA) has beneficial effects on human health. Omega-3 polyunsaturated fatty acids are precursors of eicosanoids and docosanoids, signaling molecules that control inflammation and immunity, and their dietary uptake improves a range of disorders including cardiovascular diseases, ulcerative colitis, rheumatoid arthritis, and psoriasis. The unsaturated nature of these fatty acids, however, makes them prone to oxidation, especially when they are incorporated into (membrane) phospholipids. The skin is an organ strongly exposed to oxidative stress, mainly due to solar ultraviolet radiation. Thus, increased levels of PUFA in combination with oxidative stress could cause increased local generation of oxidized lipids, whose action spectrum reaches from signaling molecules to reactive carbonyl compounds that can crosslink biomolecules. Here, we investigated whether PUFA supplements to fibroblasts are incorporated into membrane phospholipids and whether an increase of PUFA within phospholipids affects the responses of the cells to UV exposure. The redox-sensitive transcription factor Nrf2 is the major regulator of the fibroblast stress response to ultraviolet radiation or exposure to oxidized lipids. Here we addressed how Nrf2 signaling would be affected in PUFA-supplemented human dermal fibroblasts and mouse dermal fibroblasts from Nrf2-deficient and wild type mice. We found, using HPLC-tandem MS, that DHA supplements to culture media of human and murine fibroblasts were readily incorporated into phospholipids and that subsequent irradiation of the supplemented cells with UVA resulted in an increase in 1-palmitoyl-2-(epoxyisoprostane-E2)-sn-glycero-3-phosphorylcholine and Oxo-DHA esterified to phospholipid, both of which are Nrf2 agonists. Also, induction of Nrf2 target genes was enhanced in the DHA-supplemented fibroblasts after UVA irradiation. In Nrf2-deficient murine fibroblasts, the expression of the target genes was, as expected, decreased, but surprisingly, expression of TNFα and MMP13 was strongly induced in DHA-supplemented, UVA-irradiated cells. Also, Nrf2-deficient cells had increased levels of oxidized phospholipids relative to the unoxidized precursors after UVA irradiation. Our data suggest that under ultraviolet stress a functioning Nrf2 system is required to prevent DHA-induced inflammation and matrix degradation in dermal fibroblasts." @default.
• W287343231 created "2016-06-24" @default.
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• W287343231 date "2015-11-01" @default.
• W287343231 modified "2023-10-16" @default.
• W287343231 title "Nrf2 deficiency causes lipid oxidation, inflammation, and matrix-protease expression in DHA-supplemented and UVA-irradiated skin fibroblasts" @default.
• W287343231 cites W1656885848 @default.
• W287343231 cites W1896033215 @default.
• W287343231 cites W1966197860 @default.
• W287343231 cites W1972764616 @default.
• W287343231 cites W1974120192 @default.
• W287343231 cites W1976428161 @default.
• W287343231 cites W1977096397 @default.
• W287343231 cites W1977192648 @default.
• W287343231 cites W1980785057 @default.
• W287343231 cites W1982458699 @default.
• W287343231 cites W1982536530 @default.
• W287343231 cites W1985661404 @default.
• W287343231 cites W1985871840 @default.
• W287343231 cites W1990766361 @default.
• W287343231 cites W1990858299 @default.
• W287343231 cites W1991631628 @default.
• W287343231 cites W1993112302 @default.
• W287343231 cites W1993882354 @default.
• W287343231 cites W1999732266 @default.
• W287343231 cites W1999894132 @default.
• W287343231 cites W1999994059 @default.
• W287343231 cites W2000051902 @default.
• W287343231 cites W2005041437 @default.
• W287343231 cites W2009588411 @default.
• W287343231 cites W2009982232 @default.
• W287343231 cites W2012165749 @default.
• W287343231 cites W2012392941 @default.
• W287343231 cites W2020387287 @default.
• W287343231 cites W2022279037 @default.
• W287343231 cites W2024660458 @default.
• W287343231 cites W2024837178 @default.
• W287343231 cites W2030363360 @default.
• W287343231 cites W2034788880 @default.
• W287343231 cites W2035711242 @default.
• W287343231 cites W2036442695 @default.
• W287343231 cites W2040280663 @default.
• W287343231 cites W2043250256 @default.
• W287343231 cites W2047820119 @default.
• W287343231 cites W2052523921 @default.
• W287343231 cites W2053950470 @default.
• W287343231 cites W2054496327 @default.
• W287343231 cites W2055047003 @default.
• W287343231 cites W2057489128 @default.
• W287343231 cites W2060387874 @default.
• W287343231 cites W2063116304 @default.
• W287343231 cites W2065947716 @default.
• W287343231 cites W2066589243 @default.
• W287343231 cites W2067184438 @default.
• W287343231 cites W2068102724 @default.
• W287343231 cites W2068514754 @default.
• W287343231 cites W2074018752 @default.
• W287343231 cites W2074662594 @default.
• W287343231 cites W2074938084 @default.
• W287343231 cites W2080059222 @default.
• W287343231 cites W2081761761 @default.
• W287343231 cites W2085975068 @default.
• W287343231 cites W2089200582 @default.
• W287343231 cites W2089641881 @default.
• W287343231 cites W2092900714 @default.
• W287343231 cites W2093090071 @default.
• W287343231 cites W2102354517 @default.
• W287343231 cites W2105917309 @default.
• W287343231 cites W2108244474 @default.
• W287343231 cites W2108995381 @default.
• W287343231 cites W2113971187 @default.
• W287343231 cites W2123766496 @default.
• W287343231 cites W2128223919 @default.
• W287343231 cites W2130008458 @default.
• W287343231 cites W2130662287 @default.
• W287343231 cites W2131312858 @default.
• W287343231 cites W2131711814 @default.
• W287343231 cites W2134557297 @default.
• W287343231 cites W2137474942 @default.
• W287343231 cites W2143506134 @default.
• W287343231 cites W2144210822 @default.
• W287343231 cites W2144411286 @default.
• W287343231 cites W2146558971 @default.
• W287343231 cites W2148767345 @default.
• W287343231 cites W2149926124 @default.
• W287343231 cites W2153400793 @default.
• W287343231 cites W2159027398 @default.
• W287343231 cites W2161134291 @default.
• W287343231 doi "https://doi.org/10.1016/j.freeradbiomed.2015.05.006" @default.
• W287343231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25981373" @default.
• W287343231 hasPublicationYear "2015" @default.

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