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- W2873749754 abstract "Significance Cells require nuclear deformation to squeeze through tissue matrices. We have discovered that WD repeat domain 5 (WDR5; an epigenetic modulator of H3K4 methylation) is fundamental for cell polarity and migration in vitro and in vivo, independent of transcription. We have uncovered that the interactions between cells and the surrounding 3D confined conditions induce the upregulation of H3K4me3. Moreover, 3D environments control the deformability and the mechanical properties of the nucleus. We have identified that loss of WDR5 abrogates the H3K4 methylation and the nuclear changes induced by 3D conditions. Mechanistically, we found that myosin light chain kinase and myosin function were required for WDR5-mediated H3K4 methylation in 3D matrices. Our findings uncover functions of the epigenetic machinery when cells move through constricted conditions." @default.
- W2873749754 created "2018-07-19" @default.
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- W2873749754 date "2018-07-09" @default.
- W2873749754 modified "2023-10-15" @default.
- W2873749754 title "WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment" @default.
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- W2873749754 doi "https://doi.org/10.1073/pnas.1719405115" @default.
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