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- W2873769968 abstract "Le syndrome du grêle court (SGC) se caractérise par la présence d’un intestin grêle fonctionnel dont la longueur est inférieure à 200 cm. L’absorption des médicaments ayant principalement lieu par un processus de diffusion passive, elle peut être influencée par la surface d’absorption. Ainsi en cas de SGC, des doses plus élevées ou une administration par une autre voie peut s’avérer nécessaire. La présente revue a pour objectif une mise à jour des données de la littérature sur l’absorption des médicaments administrés par voie orale en cas de SGC. Malgré une utilisation large de médicaments chez ces patients, et en raison du fait qu’il s’agit d’une maladie rare, une absence de données étayées à ce sujet a été constatée, essentiellement basée sur des rapports de cas ou des études de petite taille. Les patients impliqués étaient très hétérogènes, rendant difficile l’extrapolation des données publiées chez chaque patient individuel, ce qui souligne l’importance d’une anticipation, de la mise en place d’un suivi clinique et/ou biologique pour guider la pharmacothérapie chez ce type de patients. Short bowel syndrome (SBS) occurs when a patient is left with less than 200 cm of functional small intestine. Drug absorption is mostly a passive process and can be affected by the surface area of the remaining gastrointestinal tract. Oral medication absorption is often impaired and larger doses, or other administration routes may be required. Although patients with SBS do need pharmacotherapy for symptoms associated with their pathology or for other comorbidities, there are few published case reports on drug absorption, and few studies have been conducted in small patients’ samples. Moreover, due to the highly heterogeneous nature of this patient population, it is difficult to directly apply the findings of the published literature to specific patients. Drug dosages should be guided by the monitoring of clinical endpoints and/or of biomarkers." @default.
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- W2873769968 date "2018-09-01" @default.
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- W2873769968 title "Absorption des médicaments lors de syndrome du grêle court" @default.
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- W2873769968 doi "https://doi.org/10.1016/j.nupar.2018.05.004" @default.
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