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- W2874613 abstract "Modified oligos (AON), with pure 2′, 4′-locked 7′S- or 7′R-Me-cLNA-A, -G, -MeC, and -T (Upadhayaya et al., J Org Chem 76:4408–4431, 2011; Srivastava et al., J Am Chem Soc 129:8362–8379, 2007), show higher RNA affinity and RNA selectivity, highly improved exonuclease (SVPDE), and blood serum stabilities in comparison with native oligos as well as maintained or higher RNase H recruitment capability depending upon the modification site. The AON with 7′S-Me-cLNA-MeC is found to be ~40 times more stable against SVPDE than 7′S- and 7′R-Me-cLNA-T-modified AONs, which are in turn much more stable than 7′S- and 7′R-Me-cLNA-A- and G-modified counterparts. The T m increase of the duplexes is found to be dependent on the AON-sequence context, -modification site, and the cLNA diastereomer type used (7′S or 7′R). MD simulations of the AON/RNA duplexes with 7′S- or 7′R-Me-cLNA have demonstrated that the modifications have only small local effect on the duplex structures, stacking and Watson–Crick base pairing." @default.
- W2874613 created "2016-06-24" @default.
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- W2874613 date "2014-01-01" @default.
- W2874613 modified "2023-10-18" @default.
- W2874613 title "Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties" @default.
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- W2874613 doi "https://doi.org/10.1007/978-3-642-54452-1_12" @default.
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