FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W28750135> ?p ?o ?g. }

• W28750135 endingPage "25" @default.
• W28750135 startingPage "319" @default.
• W28750135 abstract "Tamoxifen, now in use in the breast cancer clinic worldwide, was a study subject of controversy showing an estrogenic property on one occasion and an anti-estrogenic property on another occasion. The outcomes of 4 case-control studies of tamoxifen use were disclosed through 4 publications in 1998. The contents of these reports were intriguing, not only to surgeons of breast cancer clinics, but also to researchers of oncological science in general. The results of 4 research groups, being compatible with each other, were summarized in succession as follows: a) long-term use of tamoxifen reduced the occurrence of estrogen receptor (ER)-positive tumors by 69%, but no difference in the occurrence of ER(-) tumors was seen; b) the incidence of endometrial cancer was increased in the tamoxifen group; c) in women who did not have breast cancer and who had had a hysterectomy, there was no difference of breast cancer occurrence between the placebo- and tamoxifen-arms. Nevertheless, there was a statistically significant reduction of breast cancer among women receiving tamoxifen who also used hormone-replacement therapy during the trial; d) there was also no case-control difference of breast cancer occurrence between tamoxifen- and placebo-groups, when tested in a healthy population with a strong family history; e) the beneficial effect of long term use of tamoxifen in patients with early breast cancer, as assessed in terms of recurrence reduction, survival improvement and suppression of a contralateral tumor growth, was restricted to ER(+) patients; f) there was a positive correlation between the duration of tamoxifen use and the occurrence of endometrial cancer. All these observations provide strong support to the concept of the steroid criminal theory of human carcinogenesis in general. On the basis of both tamoxifen data and other information surrounding the hormonal aspect of human carcinogenesis of multiple tumors including breast cancer, we propose that the steroid generating system, as linked to the ever changing environment, plays a cardinal role as the transmitter of steroidal signals that can be taken as a go sign by the local oncogene-tumor suppressor gene complex of one target tissue and as a stop sign by that of another target tissue. The fitness of the tamoxifen data to the steroid carcinogenesis concept was discussed in the light of experimental pathology of chemical carcinogens, including the mammocarcinogen 7,12-dimethyl-benz(a)anthracene." @default.
• W28750135 created "2016-06-24" @default.
• W28750135 creator A5019599463 @default.
• W28750135 creator A5041824293 @default.
• W28750135 date "2001-11-07" @default.
• W28750135 modified "2023-09-23" @default.
• W28750135 title "The nature of tamoxifen action in the control of female breast cancer." @default.
• W28750135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11695224" @default.
• W28750135 hasPublicationYear "2001" @default.
• W28750135 type Work @default.
• W28750135 sameAs 28750135 @default.
• W28750135 citedByCount "1" @default.
• W28750135 crossrefType "journal-article" @default.
• W28750135 hasAuthorship W28750135A5019599463 @default.
• W28750135 hasAuthorship W28750135A5041824293 @default.
• W28750135 hasConcept C120665830 @default.
• W28750135 hasConcept C121332964 @default.
• W28750135 hasConcept C121608353 @default.
• W28750135 hasConcept C126322002 @default.
• W28750135 hasConcept C142724271 @default.
• W28750135 hasConcept C143998085 @default.
• W28750135 hasConcept C204787440 @default.
• W28750135 hasConcept C27081682 @default.
• W28750135 hasConcept C2777164284 @default.
• W28750135 hasConcept C2777176818 @default.
• W28750135 hasConcept C2908647359 @default.
• W28750135 hasConcept C29456083 @default.
• W28750135 hasConcept C530470458 @default.
• W28750135 hasConcept C61511704 @default.
• W28750135 hasConcept C71924100 @default.
• W28750135 hasConcept C84606932 @default.
• W28750135 hasConcept C99454951 @default.
• W28750135 hasConceptScore W28750135C120665830 @default.
• W28750135 hasConceptScore W28750135C121332964 @default.
• W28750135 hasConceptScore W28750135C121608353 @default.
• W28750135 hasConceptScore W28750135C126322002 @default.
• W28750135 hasConceptScore W28750135C142724271 @default.
• W28750135 hasConceptScore W28750135C143998085 @default.
• W28750135 hasConceptScore W28750135C204787440 @default.
• W28750135 hasConceptScore W28750135C27081682 @default.
• W28750135 hasConceptScore W28750135C2777164284 @default.
• W28750135 hasConceptScore W28750135C2777176818 @default.
• W28750135 hasConceptScore W28750135C2908647359 @default.
• W28750135 hasConceptScore W28750135C29456083 @default.
• W28750135 hasConceptScore W28750135C530470458 @default.
• W28750135 hasConceptScore W28750135C61511704 @default.
• W28750135 hasConceptScore W28750135C71924100 @default.
• W28750135 hasConceptScore W28750135C84606932 @default.
• W28750135 hasConceptScore W28750135C99454951 @default.
• W28750135 hasIssue "4" @default.
• W28750135 hasLocation W287501351 @default.
• W28750135 hasOpenAccess W28750135 @default.
• W28750135 hasPrimaryLocation W287501351 @default.
• W28750135 hasRelatedWork W129745277 @default.
• W28750135 hasRelatedWork W1994602095 @default.
• W28750135 hasRelatedWork W2043866629 @default.
• W28750135 hasRelatedWork W2133597000 @default.
• W28750135 hasRelatedWork W2322892359 @default.
• W28750135 hasRelatedWork W2376231494 @default.
• W28750135 hasRelatedWork W2496465202 @default.
• W28750135 hasRelatedWork W259818872 @default.
• W28750135 hasRelatedWork W3200346841 @default.
• W28750135 hasRelatedWork W4220982455 @default.
• W28750135 hasVolume "15" @default.
• W28750135 isParatext "false" @default.
• W28750135 isRetracted "false" @default.
• W28750135 magId "28750135" @default.
• W28750135 workType "article" @default.