Matches in SemOpenAlex for { <https://semopenalex.org/work/W287558536> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W287558536 endingPage "296" @default.
- W287558536 startingPage "287" @default.
- W287558536 abstract "RSR13 is a synthetic allosteric modifier of hemoglobin that decreases the oxygen-binding affinity of hemoglobin, increasing the P50. As a result, tissue oxygen tension is expected to increase. Using the capabilities of in vivo EPR, we directly examined the effect of RSR13 on brain pO2 in rats and the relationship between any change in brain oxygenation and changes in physiological parameters, including blood gases. The brain pO2 and arterial blood paO2 were increased significantly (p < 0.005) following RSR13 administration. The peak increase of brain tissue pO2 was 8.8 +/- 1.2 mm Hg in the animals receiving 150 mg/kg RSR13 and 13 +/- 3 mm Hg in the animals receiving 300 mg/kg RSR13. There was no difference among groups in MBP, heart rate, paCO2, pH, or HCO3. These data indicate that in anesthetized rats, RSR13 dose-dependently increases brain pO2 without affecting other physiologic parameters. This capability is likely to be very useful in circumstances where the pO2 of the brain is compromised." @default.
- W287558536 created "2016-06-24" @default.
- W287558536 creator A5007422738 @default.
- W287558536 creator A5025813719 @default.
- W287558536 creator A5048327632 @default.
- W287558536 creator A5065233597 @default.
- W287558536 creator A5070368902 @default.
- W287558536 date "2003-01-01" @default.
- W287558536 modified "2023-10-08" @default.
- W287558536 title "The Dose-Dependent Effect of RSR13, a Synthetic Allosteric Modifier of Hemoglobin, on Physiological Parameters and Brain Tissue Oxygenation in Rats" @default.
- W287558536 cites W1979678709 @default.
- W287558536 cites W2002500745 @default.
- W287558536 cites W2087032325 @default.
- W287558536 cites W2119304399 @default.
- W287558536 cites W2142381864 @default.
- W287558536 cites W2158639810 @default.
- W287558536 cites W2303560493 @default.
- W287558536 doi "https://doi.org/10.1007/978-1-4615-0075-9_27" @default.
- W287558536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14562725" @default.
- W287558536 hasPublicationYear "2003" @default.
- W287558536 type Work @default.
- W287558536 sameAs 287558536 @default.
- W287558536 citedByCount "15" @default.
- W287558536 countsByYear W2875585362014 @default.
- W287558536 countsByYear W2875585362017 @default.
- W287558536 countsByYear W2875585362018 @default.
- W287558536 countsByYear W2875585362021 @default.
- W287558536 countsByYear W2875585362023 @default.
- W287558536 crossrefType "book-chapter" @default.
- W287558536 hasAuthorship W287558536A5007422738 @default.
- W287558536 hasAuthorship W287558536A5025813719 @default.
- W287558536 hasAuthorship W287558536A5048327632 @default.
- W287558536 hasAuthorship W287558536A5065233597 @default.
- W287558536 hasAuthorship W287558536A5070368902 @default.
- W287558536 hasConcept C104317684 @default.
- W287558536 hasConcept C126322002 @default.
- W287558536 hasConcept C134018914 @default.
- W287558536 hasConcept C150903083 @default.
- W287558536 hasConcept C166342909 @default.
- W287558536 hasConcept C170493617 @default.
- W287558536 hasConcept C178790620 @default.
- W287558536 hasConcept C185592680 @default.
- W287558536 hasConcept C207001950 @default.
- W287558536 hasConcept C2778917026 @default.
- W287558536 hasConcept C2779537118 @default.
- W287558536 hasConcept C2986936838 @default.
- W287558536 hasConcept C2993207723 @default.
- W287558536 hasConcept C42219234 @default.
- W287558536 hasConcept C540031477 @default.
- W287558536 hasConcept C55493867 @default.
- W287558536 hasConcept C70289976 @default.
- W287558536 hasConcept C71924100 @default.
- W287558536 hasConcept C86339819 @default.
- W287558536 hasConcept C86803240 @default.
- W287558536 hasConcept C98270193 @default.
- W287558536 hasConcept C98274493 @default.
- W287558536 hasConceptScore W287558536C104317684 @default.
- W287558536 hasConceptScore W287558536C126322002 @default.
- W287558536 hasConceptScore W287558536C134018914 @default.
- W287558536 hasConceptScore W287558536C150903083 @default.
- W287558536 hasConceptScore W287558536C166342909 @default.
- W287558536 hasConceptScore W287558536C170493617 @default.
- W287558536 hasConceptScore W287558536C178790620 @default.
- W287558536 hasConceptScore W287558536C185592680 @default.
- W287558536 hasConceptScore W287558536C207001950 @default.
- W287558536 hasConceptScore W287558536C2778917026 @default.
- W287558536 hasConceptScore W287558536C2779537118 @default.
- W287558536 hasConceptScore W287558536C2986936838 @default.
- W287558536 hasConceptScore W287558536C2993207723 @default.
- W287558536 hasConceptScore W287558536C42219234 @default.
- W287558536 hasConceptScore W287558536C540031477 @default.
- W287558536 hasConceptScore W287558536C55493867 @default.
- W287558536 hasConceptScore W287558536C70289976 @default.
- W287558536 hasConceptScore W287558536C71924100 @default.
- W287558536 hasConceptScore W287558536C86339819 @default.
- W287558536 hasConceptScore W287558536C86803240 @default.
- W287558536 hasConceptScore W287558536C98270193 @default.
- W287558536 hasConceptScore W287558536C98274493 @default.
- W287558536 hasLocation W2875585361 @default.
- W287558536 hasLocation W2875585362 @default.
- W287558536 hasOpenAccess W287558536 @default.
- W287558536 hasPrimaryLocation W2875585361 @default.
- W287558536 hasRelatedWork W1971782741 @default.
- W287558536 hasRelatedWork W2018921526 @default.
- W287558536 hasRelatedWork W2046450796 @default.
- W287558536 hasRelatedWork W2050360559 @default.
- W287558536 hasRelatedWork W2169750653 @default.
- W287558536 hasRelatedWork W2195592873 @default.
- W287558536 hasRelatedWork W2370357204 @default.
- W287558536 hasRelatedWork W2394644918 @default.
- W287558536 hasRelatedWork W2939998722 @default.
- W287558536 hasRelatedWork W3005062988 @default.
- W287558536 isParatext "false" @default.
- W287558536 isRetracted "false" @default.
- W287558536 magId "287558536" @default.
- W287558536 workType "book-chapter" @default.