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- W28755959 abstract "There is now a vast amount of data which provides absolute proof that both T and B lymphocytes are capable of manifesting immunological specificity. This is exemplified by the fact that specificity exists in immune responses characteristic of each cell population—thus, cell-mediated immunity such as delayed hypersensitivity, which is predominantly a function of T cells, and antibody production, which is mediated by B cells are specific events in the immune system. In immune responses to T cell-independent antigens (see Chapter IX ) in which B cells develop antibody responses in the relative absence of T cell function, such cells truly reflect specificity for the antigens involved. The situation is somewhat more complex in humoral immune responses to antigens where T and B cell cooperative interactions are required (see Chapter X ), but conclusive evidence exists that each of the respective cell classes participating in such responses manifest specificity for antigenic determinants stimulating the response. In this chapter, we will consider the nature of the functional evidence demonstrating specificity of T and B lymphocytes, the comparative specificity of the two lymphocyte classes, and what is known about the nature of the antigen-binding receptors on each cell class." @default.
- W28755959 created "2016-06-24" @default.
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- W28755959 date "1977-01-01" @default.
- W28755959 modified "2023-09-26" @default.
- W28755959 title "Immunological Specificity of Immunocompetent Lymphocytes" @default.
- W28755959 doi "https://doi.org/10.1016/b978-0-12-401640-8.50012-5" @default.
- W28755959 hasPublicationYear "1977" @default.
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