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• W2875686737 endingPage "387" @default.
• W2875686737 startingPage "376" @default.
• W2875686737 abstract "Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABA A receptors (GABA A R) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GABA depends on the balance of chloride influx by Na + -K + -Cl – cotransporter 1 (NKCC1) and chloride efflux by K + -Cl – cotransporters (KCCs). Excitatory responses to GABA can be blocked by inhibition of the inward chloride cotransporter, NKCC1, with the loop diuretic bumetanide. Here we investigated the role of NKCC1 activity in phase shifting the circadian pacemaker in response to photic and nonphotic signals in male Syrian hamsters housed in constant darkness. In the early subjective night (CT 13.5), injection of bumetanide into the SCN reduced light-induced phase delays. However, during the late subjective night (CT 19), bumetanide administration did not alter light-induced phase advances. Injection of bumetanide during the subjective day (CT 6) did not alter the phase of free-running circadian rhythms but attenuated phase advances induced by injection of the GABA A R agonist muscimol into the SCN. These data support the hypothesis that the excitatory effects of endogenously released GABA contribute to the ability of light to induce phase delays, thereby contributing to the most important function of the circadian system, its entrainment with the day-night cycle. Further, the finding that bumetanide inhibits the phase-advancing effects of muscimol during the subjective day supports the hypothesis that the excitatory responses to GABA also contribute to the ability of nonphotic stimuli to phase shift the circadian pacemaker." @default.
• W2875686737 created "2018-07-19" @default.
• W2875686737 creator A5017644511 @default.
• W2875686737 creator A5026359004 @default.
• W2875686737 creator A5088484063 @default.
• W2875686737 date "2018-07-05" @default.
• W2875686737 modified "2023-10-02" @default.
• W2875686737 title "Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus" @default.
• W2875686737 cites W1483484597 @default.
• W2875686737 cites W1558885344 @default.
• W2875686737 cites W1565105956 @default.
• W2875686737 cites W1668541200 @default.
• W2875686737 cites W1866481691 @default.
• W2875686737 cites W1897570857 @default.
• W2875686737 cites W1931825370 @default.
• W2875686737 cites W1952213740 @default.
• W2875686737 cites W1961084257 @default.
• W2875686737 cites W1966007281 @default.
• W2875686737 cites W1967340734 @default.
• W2875686737 cites W1967444438 @default.
• W2875686737 cites W1968244525 @default.
• W2875686737 cites W1968701192 @default.
• W2875686737 cites W1968954425 @default.
• W2875686737 cites W1977598989 @default.
• W2875686737 cites W1986480559 @default.
• W2875686737 cites W1986608768 @default.
• W2875686737 cites W1990356805 @default.
• W2875686737 cites W1995994950 @default.
• W2875686737 cites W2001711337 @default.
• W2875686737 cites W2003916765 @default.
• W2875686737 cites W2009077913 @default.
• W2875686737 cites W2009477241 @default.
• W2875686737 cites W2009914302 @default.
• W2875686737 cites W2011065426 @default.
• W2875686737 cites W2013334578 @default.
• W2875686737 cites W2014148221 @default.
• W2875686737 cites W2015292556 @default.
• W2875686737 cites W2015402598 @default.
• W2875686737 cites W2016321438 @default.
• W2875686737 cites W2017791457 @default.
• W2875686737 cites W2019909157 @default.
• W2875686737 cites W2020340826 @default.
• W2875686737 cites W2030030875 @default.
• W2875686737 cites W2030536090 @default.
• W2875686737 cites W2033876509 @default.
• W2875686737 cites W2034834392 @default.
• W2875686737 cites W2034906099 @default.
• W2875686737 cites W2037176845 @default.
• W2875686737 cites W2042015732 @default.
• W2875686737 cites W2043815378 @default.
• W2875686737 cites W2046244565 @default.
• W2875686737 cites W2047678578 @default.
• W2875686737 cites W2051483750 @default.
• W2875686737 cites W2052348462 @default.
• W2875686737 cites W2052695273 @default.
• W2875686737 cites W2059495268 @default.
• W2875686737 cites W2062436189 @default.
• W2875686737 cites W2068615644 @default.
• W2875686737 cites W2069179900 @default.
• W2875686737 cites W2078689239 @default.
• W2875686737 cites W2082980979 @default.
• W2875686737 cites W2084364458 @default.
• W2875686737 cites W2090455987 @default.
• W2875686737 cites W2092719147 @default.
• W2875686737 cites W2093148210 @default.
• W2875686737 cites W2094426488 @default.
• W2875686737 cites W2095668083 @default.
• W2875686737 cites W2095783413 @default.
• W2875686737 cites W2108130957 @default.
• W2875686737 cites W2114688004 @default.
• W2875686737 cites W2115857241 @default.
• W2875686737 cites W2116665706 @default.
• W2875686737 cites W2127447141 @default.
• W2875686737 cites W2133347535 @default.
• W2875686737 cites W2136892259 @default.
• W2875686737 cites W2136983368 @default.
• W2875686737 cites W2141765816 @default.
• W2875686737 cites W2147933292 @default.
• W2875686737 cites W2150894749 @default.
• W2875686737 cites W2161711916 @default.
• W2875686737 cites W2164003143 @default.
• W2875686737 cites W2169553571 @default.
• W2875686737 cites W2170283405 @default.
• W2875686737 cites W2172296786 @default.
• W2875686737 cites W2258161268 @default.
• W2875686737 cites W2316540876 @default.
• W2875686737 cites W2321111997 @default.
• W2875686737 cites W2345421990 @default.
• W2875686737 cites W2553469214 @default.
• W2875686737 cites W2607099659 @default.
• W2875686737 cites W2745655002 @default.
• W2875686737 cites W4244611911 @default.
• W2875686737 doi "https://doi.org/10.1177/0748730418782820" @default.
• W2875686737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6419757" @default.
• W2875686737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29974800" @default.
• W2875686737 hasPublicationYear "2018" @default.
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