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• W2877442110 abstract "An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share a similar profile of electrophysiology, metabolism, and early sensory responses, neuromodulation is often different and therefore may constitute a key mechanism enabling perceptual awareness. Specifically, noradrenaline improves sensory responses, correlates with orienting toward behaviorally relevant stimuli, and is markedly reduced during sleep, while experience is largely disconnected from external events. Despite correlative evidence hinting at a relationship between noradrenaline and perception, causal evidence remains absent. Here, we pharmacologically down- and upregulated noradrenaline signaling in healthy volunteers using clonidine and reboxetine in double-blind placebo-controlled experiments, testing the effects on perceptual abilities and visually evoked electroencephalography (EEG) and fMRI responses. We found that detection sensitivity, discrimination accuracy, and subjective visibility change in accordance with noradrenaline (NE) levels, whereas decision bias (criterion) is not affected. Similarly, noradrenaline increases the consistency of EEG visually evoked potentials, while lower noradrenaline levels delay response components around 200 ms. Furthermore, blood-oxygen-level-dependent (BOLD) fMRI activations in high-order visual cortex selectively vary along with noradrenaline signaling. Taken together, these results point to noradrenaline as a key factor causally linking visual awareness to external world events. VIDEO ABSTRACT." @default.
• W2877442110 created "2018-07-19" @default.
• W2877442110 creator A5022641031 @default.
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• W2877442110 creator A5067853966 @default.
• W2877442110 creator A5069158944 @default.
• W2877442110 date "2018-07-01" @default.
• W2877442110 modified "2023-10-12" @default.
• W2877442110 title "Noradrenaline Modulates Visual Perception and Late Visually Evoked Activity" @default.
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• W2877442110 doi "https://doi.org/10.1016/j.cub.2018.05.051" @default.
• W2877442110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29983318" @default.
• W2877442110 hasPublicationYear "2018" @default.
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