Matches in SemOpenAlex for { <https://semopenalex.org/work/W28779746> ?p ?o ?g. }
- W28779746 endingPage "238" @default.
- W28779746 startingPage "226" @default.
- W28779746 abstract "In experimental models of epilepsy, single and recurrent seizures are often used in an attempt to determine the effects of the seizures themselves on mammalian brain function. These models attempt to emulate as many features as possible of their human disease counterparts without many of the confounding factors such as underlying disease processes and medication effects. Numerous models have been used in the past to address different questions. Nevertheless, the basic questions are often the same: 1. Do seizures cause long-term damage? 2. Do seizures predispose to chronic epilepsy (epileptogenesis), that is long-term spontaneous repetitive seizures? 3. Are these results developmentally regulated? 4. Are the underlying mechanisms of epileptogenesis and brain damage related? In pursuing these questions, the goal is to determine how seizures exert their effects and to minimize any side effects from the methods employed to induce the seizures themselves. This requires a detailed characterization of the methods used to induce seizures. In this chapter, we will review the literature regarding the tetanus toxin model of chronic epilepsy with regard to its mechanisms of action, clinical comparisons, how it is experimentally implemented and the results obtained thus far. These results will be compared to other models of chronic epilepsy in order to make generalizations about the effects of repetitive seizures in adult and early life. At this time, it appears that repetitive seizures cause long-term changes in learning ability and may cause a predisposition to chronic seizures at all ages. In younger animals, both features of learning impairment and epilepsy are not typically associated with cell loss as they are in adult animals. At all ages, some form of synaptic reorganization has been demonstrated to occur." @default.
- W28779746 created "2016-06-24" @default.
- W28779746 creator A5037953901 @default.
- W28779746 creator A5052445295 @default.
- W28779746 date "2004-01-01" @default.
- W28779746 modified "2023-10-16" @default.
- W28779746 title "The Tetanus Toxin Model of Chronic Epilepsy" @default.
- W28779746 cites W1568317937 @default.
- W28779746 cites W1583117393 @default.
- W28779746 cites W1599165949 @default.
- W28779746 cites W1770278459 @default.
- W28779746 cites W1812286656 @default.
- W28779746 cites W1874385193 @default.
- W28779746 cites W1964389840 @default.
- W28779746 cites W1965058807 @default.
- W28779746 cites W1968187083 @default.
- W28779746 cites W1971482493 @default.
- W28779746 cites W1972897107 @default.
- W28779746 cites W1973589958 @default.
- W28779746 cites W1974697811 @default.
- W28779746 cites W1974703378 @default.
- W28779746 cites W1976781159 @default.
- W28779746 cites W1977820012 @default.
- W28779746 cites W1977989536 @default.
- W28779746 cites W1978705572 @default.
- W28779746 cites W1981564602 @default.
- W28779746 cites W1983449473 @default.
- W28779746 cites W1987196832 @default.
- W28779746 cites W1992034665 @default.
- W28779746 cites W1992464116 @default.
- W28779746 cites W1994297815 @default.
- W28779746 cites W1995536650 @default.
- W28779746 cites W2000987515 @default.
- W28779746 cites W2001871190 @default.
- W28779746 cites W2007464173 @default.
- W28779746 cites W2007645138 @default.
- W28779746 cites W2010674841 @default.
- W28779746 cites W2013186114 @default.
- W28779746 cites W2016266703 @default.
- W28779746 cites W2016444540 @default.
- W28779746 cites W2017359588 @default.
- W28779746 cites W2024978909 @default.
- W28779746 cites W2030638243 @default.
- W28779746 cites W2033500343 @default.
- W28779746 cites W2033520740 @default.
- W28779746 cites W2035082265 @default.
- W28779746 cites W2045356884 @default.
- W28779746 cites W2045932599 @default.
- W28779746 cites W2047926228 @default.
- W28779746 cites W2049511526 @default.
- W28779746 cites W2054164561 @default.
- W28779746 cites W2054887752 @default.
- W28779746 cites W2060985279 @default.
- W28779746 cites W2061211087 @default.
- W28779746 cites W2063938540 @default.
- W28779746 cites W2070570723 @default.
- W28779746 cites W2072358297 @default.
- W28779746 cites W2072562017 @default.
- W28779746 cites W2073245867 @default.
- W28779746 cites W2076342729 @default.
- W28779746 cites W2081311008 @default.
- W28779746 cites W2083867490 @default.
- W28779746 cites W2086490904 @default.
- W28779746 cites W2086681063 @default.
- W28779746 cites W2091026227 @default.
- W28779746 cites W2091441008 @default.
- W28779746 cites W2092959372 @default.
- W28779746 cites W2094640635 @default.
- W28779746 cites W2106645298 @default.
- W28779746 cites W2121106128 @default.
- W28779746 cites W2141285427 @default.
- W28779746 cites W2142925815 @default.
- W28779746 cites W2149846553 @default.
- W28779746 cites W2152371902 @default.
- W28779746 cites W2153741312 @default.
- W28779746 cites W2159526304 @default.
- W28779746 cites W2321601479 @default.
- W28779746 cites W2339414600 @default.
- W28779746 cites W2341395058 @default.
- W28779746 cites W2408734738 @default.
- W28779746 cites W4301247226 @default.
- W28779746 cites W4301964731 @default.
- W28779746 doi "https://doi.org/10.1007/978-1-4757-6376-8_16" @default.
- W28779746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15250597" @default.
- W28779746 hasPublicationYear "2004" @default.
- W28779746 type Work @default.
- W28779746 sameAs 28779746 @default.
- W28779746 citedByCount "30" @default.
- W28779746 countsByYear W287797462012 @default.
- W28779746 countsByYear W287797462013 @default.
- W28779746 countsByYear W287797462014 @default.
- W28779746 countsByYear W287797462015 @default.
- W28779746 countsByYear W287797462017 @default.
- W28779746 countsByYear W287797462021 @default.
- W28779746 countsByYear W287797462022 @default.
- W28779746 countsByYear W287797462023 @default.
- W28779746 crossrefType "book-chapter" @default.
- W28779746 hasAuthorship W28779746A5037953901 @default.