FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2878974736> ?p ?o ?g. }

• W2878974736 abstract "In the early stage of severe burn, patients often exhibit a high level of inflammatory mediators in blood and are likely to develop sepsis. High-volume haemofiltration (HVHF) can eliminate these inflammatory mediators. We hypothesised that early application of HVHF may be beneficial in reducing sepsis and improving the prognosis of patients with severe burns. Adults patients with burns ≥ 50% total burn surface area (TBSA) and in whom the sum of deep partial and full-thickness burn areas was ≥ 30% were enrolled in this randomised prospective study, and they were divided into control (41 cases) and HVHF (41 cases) groups. Patients in the control group received standard management for major burns, whereas the HVHF group additionally received HVHF treatment (65 ml/kg/h for 3 consecutive days) within 3 days after burn. The incidence of sepsis and mortality, some laboratory data, levels of inflammatory cytokines in the blood, HLA-DR expression on CD14+ peripheral blood monocytes, the proportion of CD25+Foxp3+ in CD4+ T lymphocytes, and the counts of CD3+, CD4+ and CD8+ T lymphocytes were recorded within 28 days post-burn. The incidence of sepsis, septic shock and duration of vasopressor treatment were decreased significantly in the HVHF group. In addition, in the subgroup of patients with burns ≥ 80% TBSA, the 90-day mortality showed significant decreases in the HVHF group. The ratio of arterial oxygen partial pressure to the fraction of inspiration oxygen was improved after HVHF treatment. In the patients who received HVHF treatment, the blood levels of inflammatory cytokines, including tumour necrosis factor-α, interleukin (IL)-1β, IL-6 and IL-8, as well as the blood level of procalcitonin were found to be lower than in the control group. Moreover, higher HLA-DR expression on CD14+ monocytes and a lower proportion of CD25+Foxp3+ in CD4+ T lymphocytes were observed in the patients in the HVHF group. Early application of HVHF benefits patients with severe burns, especially for those with a greater burn area (≥ 80% TBSA), decreasing the incidence of sepsis and mortality. This effect may be attributed to its early clearance of inflammatory mediators and the recovery of the patient’s immune status. Chinese Clinical Trial Register, ChiCTR-TRC-12002616 . Registered on 24 October 2012." @default.
• W2878974736 created "2018-07-19" @default.
• W2878974736 creator A5006962593 @default.
• W2878974736 creator A5007313930 @default.
• W2878974736 creator A5008168090 @default.
• W2878974736 creator A5018662976 @default.
• W2878974736 creator A5040957569 @default.
• W2878974736 creator A5046546679 @default.
• W2878974736 creator A5050936038 @default.
• W2878974736 creator A5052676364 @default.
• W2878974736 creator A5056242959 @default.
• W2878974736 creator A5060624048 @default.
• W2878974736 creator A5061456342 @default.
• W2878974736 creator A5061559264 @default.
• W2878974736 creator A5086083710 @default.
• W2878974736 date "2018-07-06" @default.
• W2878974736 modified "2023-10-18" @default.
• W2878974736 title "Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns" @default.
• W2878974736 cites W1492950536 @default.
• W2878974736 cites W1970640275 @default.
• W2878974736 cites W1971130142 @default.
• W2878974736 cites W1984666117 @default.
• W2878974736 cites W1988733171 @default.
• W2878974736 cites W1991864206 @default.
• W2878974736 cites W1993825480 @default.
• W2878974736 cites W1995570669 @default.
• W2878974736 cites W1996871794 @default.
• W2878974736 cites W1997686080 @default.
• W2878974736 cites W2028646275 @default.
• W2878974736 cites W2030015146 @default.
• W2878974736 cites W2045675252 @default.
• W2878974736 cites W2055003843 @default.
• W2878974736 cites W2056411965 @default.
• W2878974736 cites W2071637551 @default.
• W2878974736 cites W2076753860 @default.
• W2878974736 cites W2087932263 @default.
• W2878974736 cites W2096458783 @default.
• W2878974736 cites W2097476575 @default.
• W2878974736 cites W2101013400 @default.
• W2878974736 cites W2106991436 @default.
• W2878974736 cites W2117414166 @default.
• W2878974736 cites W2118138330 @default.
• W2878974736 cites W2125444608 @default.
• W2878974736 cites W2133569121 @default.
• W2878974736 cites W2150351645 @default.
• W2878974736 cites W2152895708 @default.
• W2878974736 cites W2156110367 @default.
• W2878974736 cites W2174219248 @default.
• W2878974736 cites W2183935821 @default.
• W2878974736 cites W2326936967 @default.
• W2878974736 cites W2418381621 @default.
• W2878974736 cites W2442246762 @default.
• W2878974736 cites W2508329706 @default.
• W2878974736 cites W2583164045 @default.
• W2878974736 cites W2600087161 @default.
• W2878974736 cites W2608823051 @default.
• W2878974736 cites W2617063590 @default.
• W2878974736 cites W2620220384 @default.
• W2878974736 cites W2768952896 @default.
• W2878974736 cites W3016555942 @default.
• W2878974736 cites W4293242440 @default.
• W2878974736 cites W46876298 @default.
• W2878974736 cites W2084075464 @default.
• W2878974736 doi "https://doi.org/10.1186/s13054-018-2095-9" @default.
• W2878974736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6035411" @default.
• W2878974736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29980222" @default.
• W2878974736 hasPublicationYear "2018" @default.
• W2878974736 type Work @default.
• W2878974736 sameAs 2878974736 @default.
• W2878974736 citedByCount "34" @default.
• W2878974736 countsByYear W28789747362018 @default.
• W2878974736 countsByYear W28789747362019 @default.
• W2878974736 countsByYear W28789747362020 @default.
• W2878974736 countsByYear W28789747362021 @default.
• W2878974736 countsByYear W28789747362022 @default.
• W2878974736 countsByYear W28789747362023 @default.
• W2878974736 crossrefType "journal-article" @default.
• W2878974736 hasAuthorship W2878974736A5006962593 @default.
• W2878974736 hasAuthorship W2878974736A5007313930 @default.
• W2878974736 hasAuthorship W2878974736A5008168090 @default.
• W2878974736 hasAuthorship W2878974736A5018662976 @default.
• W2878974736 hasAuthorship W2878974736A5040957569 @default.
• W2878974736 hasAuthorship W2878974736A5046546679 @default.
• W2878974736 hasAuthorship W2878974736A5050936038 @default.
• W2878974736 hasAuthorship W2878974736A5052676364 @default.
• W2878974736 hasAuthorship W2878974736A5056242959 @default.
• W2878974736 hasAuthorship W2878974736A5060624048 @default.
• W2878974736 hasAuthorship W2878974736A5061456342 @default.
• W2878974736 hasAuthorship W2878974736A5061559264 @default.
• W2878974736 hasAuthorship W2878974736A5086083710 @default.
• W2878974736 hasBestOaLocation W28789747361 @default.
• W2878974736 hasConcept C120665830 @default.
• W2878974736 hasConcept C121332964 @default.
• W2878974736 hasConcept C126322002 @default.
• W2878974736 hasConcept C141071460 @default.
• W2878974736 hasConcept C2777628635 @default.
• W2878974736 hasConcept C2778384902 @default.
• W2878974736 hasConcept C2781300812 @default.
• W2878974736 hasConcept C42219234 @default.
• W2878974736 hasConcept C61511704 @default.

• next