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• W2880414733 abstract "Background & aims Malnutrition is common in Sub-Saharan Africa, weakening the immune function of persons living with HIV infection (PLWH). Being malnourished at the initiation of antiretroviral therapy (ART) leads to higher risk of early mortality and reduced quality of life. Thus, introduction of protein-energy-fortified macronutrient supplements at ART initiation may improve HIV treatment outcomes. This review aimed to evaluate the effectiveness of macronutrient interventions. Methods This systematic review and meta-analysis included 15 studies conducted from 2000 to 2015 among Sub-Saharan African adults. Results Six randomized controlled trials and 4 retrospective cohort studies provided data eligible for a meta-analysis. Supplementation significantly increased the overall standardized mean difference (SMD) between baseline and follow-up data in weight (SMD = 0.382, p < .001), BMI (SMD = 0.799, p < .001); fat-free mass (SMD = 0.154, p = .009); and CD4 count (SMD = 0.428, p < .001). Conclusion Protein-energy-fortified macronutrient supplementation at ART initiation may positively influence nutritional status and immunologic response in PLWH in Sub-Saharan Africa." @default.
• W2880414733 created "2018-07-19" @default.
• W2880414733 creator A5032130198 @default.
• W2880414733 creator A5041886170 @default.
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• W2880414733 date "2018-10-01" @default.
• W2880414733 modified "2023-10-14" @default.
• W2880414733 title "Effectiveness of macronutrient supplementation on nutritional status and HIV/AIDS progression: A systematic review and meta-analysis" @default.
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• W2880414733 doi "https://doi.org/10.1016/j.clnesp.2018.06.007" @default.
• W2880414733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6112859" @default.
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