FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2880795087> ?p ?o ?g. }

• W2880795087 endingPage "1013" @default.
• W2880795087 startingPage "1008" @default.
• W2880795087 abstract "Abstract Although the 5-year survival rate of chronic lymphocytic leukemia (CLL) patients has risen to &gt;80%, the only potentially curative treatment is allogeneic hematopoietic stem cell transplantation (alloHSCT). To identify possible new monoclonal antibody (mAb) drugs and targets for CLL, we previously developed a phage display–based human mAb platform to mine the antibody repertoire of patients who responded to alloHSCT. We had selected a group of highly homologous post-alloHSCT mAbs that bound to an unknown CLL cell surface antigen. Here, we show through next-generation sequencing of cDNAs encoding variable heavy-chain domains that these mAbs had a relative abundance of ∼0.1% in the post-alloHSCT antibody repertoire and were enriched ∼1,000-fold after three rounds of selection on primary CLL cells. Based on differential RNA-seq and a cell microarray screening technology for discovering human cell surface antigens, we now identify their antigen as Siglec-6. We verified this finding by flow cytometry, ELISA, siRNA knockdown, and surface plasmon resonance. Siglec-6 was broadly expressed in CLL and could be a potential target for antibody-based therapeutic interventions. Our study reaffirms the utility of post-alloHSCT antibody drug and target discovery. Cancer Immunol Res; 6(9); 1008–13. ©2018 AACR." @default.
• W2880795087 created "2018-07-19" @default.
• W2880795087 creator A5020568974 @default.
• W2880795087 creator A5021515632 @default.
• W2880795087 creator A5029621110 @default.
• W2880795087 creator A5030524385 @default.
• W2880795087 creator A5036456864 @default.
• W2880795087 creator A5044521397 @default.
• W2880795087 creator A5064076262 @default.
• W2880795087 creator A5065812703 @default.
• W2880795087 creator A5066617146 @default.
• W2880795087 creator A5074157959 @default.
• W2880795087 creator A5088287990 @default.
• W2880795087 date "2018-09-01" @default.
• W2880795087 modified "2023-09-25" @default.
• W2880795087 title "Siglec-6 on Chronic Lymphocytic Leukemia Cells Is a Target for Post-Allogeneic Hematopoietic Stem Cell Transplantation Antibodies" @default.
• W2880795087 cites W1515090907 @default.
• W2880795087 cites W1519385930 @default.
• W2880795087 cites W1971907885 @default.
• W2880795087 cites W1993160668 @default.
• W2880795087 cites W2004859446 @default.
• W2880795087 cites W2009695842 @default.
• W2880795087 cites W2011412980 @default.
• W2880795087 cites W2015091846 @default.
• W2880795087 cites W2036897871 @default.
• W2880795087 cites W2055969647 @default.
• W2880795087 cites W2066090902 @default.
• W2880795087 cites W2121210640 @default.
• W2880795087 cites W2135435448 @default.
• W2880795087 cites W2144387927 @default.
• W2880795087 cites W2154643268 @default.
• W2880795087 cites W2157107905 @default.
• W2880795087 cites W2747369917 @default.
• W2880795087 cites W2788803761 @default.
• W2880795087 doi "https://doi.org/10.1158/2326-6066.cir-18-0102" @default.
• W2880795087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125214" @default.
• W2880795087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29980538" @default.
• W2880795087 hasPublicationYear "2018" @default.
• W2880795087 type Work @default.
• W2880795087 sameAs 2880795087 @default.
• W2880795087 citedByCount "10" @default.
• W2880795087 countsByYear W28807950872019 @default.
• W2880795087 countsByYear W28807950872020 @default.
• W2880795087 countsByYear W28807950872021 @default.
• W2880795087 countsByYear W28807950872022 @default.
• W2880795087 countsByYear W28807950872023 @default.
• W2880795087 crossrefType "journal-article" @default.
• W2880795087 hasAuthorship W2880795087A5020568974 @default.
• W2880795087 hasAuthorship W2880795087A5021515632 @default.
• W2880795087 hasAuthorship W2880795087A5029621110 @default.
• W2880795087 hasAuthorship W2880795087A5030524385 @default.
• W2880795087 hasAuthorship W2880795087A5036456864 @default.
• W2880795087 hasAuthorship W2880795087A5044521397 @default.
• W2880795087 hasAuthorship W2880795087A5064076262 @default.
• W2880795087 hasAuthorship W2880795087A5065812703 @default.
• W2880795087 hasAuthorship W2880795087A5066617146 @default.
• W2880795087 hasAuthorship W2880795087A5074157959 @default.
• W2880795087 hasAuthorship W2880795087A5088287990 @default.
• W2880795087 hasBestOaLocation W28807950871 @default.
• W2880795087 hasConcept C126322002 @default.
• W2880795087 hasConcept C147483822 @default.
• W2880795087 hasConcept C159654299 @default.
• W2880795087 hasConcept C203014093 @default.
• W2880795087 hasConcept C2777408962 @default.
• W2880795087 hasConcept C2777938653 @default.
• W2880795087 hasConcept C2778461978 @default.
• W2880795087 hasConcept C28328180 @default.
• W2880795087 hasConcept C2911091166 @default.
• W2880795087 hasConcept C502942594 @default.
• W2880795087 hasConcept C542903549 @default.
• W2880795087 hasConcept C54355233 @default.
• W2880795087 hasConcept C71924100 @default.
• W2880795087 hasConcept C86803240 @default.
• W2880795087 hasConceptScore W2880795087C126322002 @default.
• W2880795087 hasConceptScore W2880795087C147483822 @default.
• W2880795087 hasConceptScore W2880795087C159654299 @default.
• W2880795087 hasConceptScore W2880795087C203014093 @default.
• W2880795087 hasConceptScore W2880795087C2777408962 @default.
• W2880795087 hasConceptScore W2880795087C2777938653 @default.
• W2880795087 hasConceptScore W2880795087C2778461978 @default.
• W2880795087 hasConceptScore W2880795087C28328180 @default.
• W2880795087 hasConceptScore W2880795087C2911091166 @default.
• W2880795087 hasConceptScore W2880795087C502942594 @default.
• W2880795087 hasConceptScore W2880795087C542903549 @default.
• W2880795087 hasConceptScore W2880795087C54355233 @default.
• W2880795087 hasConceptScore W2880795087C71924100 @default.
• W2880795087 hasConceptScore W2880795087C86803240 @default.
• W2880795087 hasFunder F4320332161 @default.
• W2880795087 hasIssue "9" @default.
• W2880795087 hasLocation W28807950871 @default.
• W2880795087 hasLocation W28807950872 @default.
• W2880795087 hasLocation W28807950873 @default.
• W2880795087 hasLocation W28807950874 @default.
• W2880795087 hasOpenAccess W2880795087 @default.
• W2880795087 hasPrimaryLocation W28807950871 @default.
• W2880795087 hasRelatedWork W1602847563 @default.
• W2880795087 hasRelatedWork W1943797027 @default.
• W2880795087 hasRelatedWork W1991697133 @default.

• next