FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2880866428> ?p ?o ?g. }

• W2880866428 abstract "Abstract Heme oxygenase-1 (HO-1; encoded by Hmox1 ), a downstream target of the Nrf2 transcription factor, has been postulated to be a negative regulator of osteoclasts (OCLs) differentiation. Here, we further explored such a hypothesis by examining HO-1 effects in different stages of osteoclastogenesis. We confirmed the inhibition of the expression of OCLs markers by Nrf2. In contrast, both the lack of the active Hmox1 gene or HO-1 silencing in OCLs precursor cells, bone marrow macrophages (BMMs), decreased their differentiation towards OCLs, as indicated by the analysis of OCLs markers such as TRAP. However, no effect of HO-1 deficiency was observed when HO-1 expression was silenced in BMMs or RAW264.7 macrophage cell line pre-stimulated with RANKL (considered as early-stage OCLs). Moreover, cobalt protoporphyrin IX (CoPPIX) or hemin, the known HO-1 inducers, inhibited OCLs markers both in RANKL-stimulated RAW264.7 cells and BMMs. Strikingly, a similar effect occurred in HO-1 −/− cells, indicating HO-1-independent activity of CoPPIX and hemin. Interestingly, plasma of HO-1 −/− mice contained higher TRAP levels, which suggests an increased number of bone-resorbing OCLs in the absence of HO-1 in vivo . In conclusion, our data indicate that HO-1 is involved in the response of bone marrow macrophages to RANKL and the induction of OCLs markers, but it is dispensable in early-stage OCLs. However, in vivo HO-1 appears to inhibit OCLs formation." @default.
• W2880866428 created "2018-07-19" @default.
• W2880866428 creator A5002654259 @default.
• W2880866428 creator A5024795564 @default.
• W2880866428 creator A5026938834 @default.
• W2880866428 creator A5033236428 @default.
• W2880866428 creator A5037185622 @default.
• W2880866428 creator A5047354338 @default.
• W2880866428 creator A5075717051 @default.
• W2880866428 creator A5082864592 @default.
• W2880866428 creator A5087849258 @default.
• W2880866428 date "2018-07-17" @default.
• W2880866428 modified "2023-10-16" @default.
• W2880866428 title "Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis" @default.
• W2880866428 cites W1523693806 @default.
• W2880866428 cites W1803753513 @default.
• W2880866428 cites W1838439206 @default.
• W2880866428 cites W1971720206 @default.
• W2880866428 cites W1975505424 @default.
• W2880866428 cites W1977107801 @default.
• W2880866428 cites W1984845821 @default.
• W2880866428 cites W1985260819 @default.
• W2880866428 cites W2001019228 @default.
• W2880866428 cites W2001158499 @default.
• W2880866428 cites W2002831974 @default.
• W2880866428 cites W2009378013 @default.
• W2880866428 cites W2010436642 @default.
• W2880866428 cites W2023261386 @default.
• W2880866428 cites W2035019741 @default.
• W2880866428 cites W2036368043 @default.
• W2880866428 cites W2039898654 @default.
• W2880866428 cites W2045906656 @default.
• W2880866428 cites W2062145087 @default.
• W2880866428 cites W2064346787 @default.
• W2880866428 cites W2071768625 @default.
• W2880866428 cites W2082612168 @default.
• W2880866428 cites W2083117490 @default.
• W2880866428 cites W2085239490 @default.
• W2880866428 cites W2093252878 @default.
• W2880866428 cites W209520997 @default.
• W2880866428 cites W2098975624 @default.
• W2880866428 cites W2100359187 @default.
• W2880866428 cites W2102353819 @default.
• W2880866428 cites W2109360536 @default.
• W2880866428 cites W2122518329 @default.
• W2880866428 cites W2132541910 @default.
• W2880866428 cites W2134483023 @default.
• W2880866428 cites W2139996507 @default.
• W2880866428 cites W2160546595 @default.
• W2880866428 cites W2233394289 @default.
• W2880866428 cites W2340338776 @default.
• W2880866428 cites W2395308302 @default.
• W2880866428 cites W2577923077 @default.
• W2880866428 cites W2586218563 @default.
• W2880866428 doi "https://doi.org/10.1038/s41598-018-29122-1" @default.
• W2880866428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6050304" @default.
• W2880866428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30018287" @default.
• W2880866428 hasPublicationYear "2018" @default.
• W2880866428 type Work @default.
• W2880866428 sameAs 2880866428 @default.
• W2880866428 citedByCount "24" @default.
• W2880866428 countsByYear W28808664282018 @default.
• W2880866428 countsByYear W28808664282019 @default.
• W2880866428 countsByYear W28808664282020 @default.
• W2880866428 countsByYear W28808664282021 @default.
• W2880866428 countsByYear W28808664282022 @default.
• W2880866428 countsByYear W28808664282023 @default.
• W2880866428 crossrefType "journal-article" @default.
• W2880866428 hasAuthorship W2880866428A5002654259 @default.
• W2880866428 hasAuthorship W2880866428A5024795564 @default.
• W2880866428 hasAuthorship W2880866428A5026938834 @default.
• W2880866428 hasAuthorship W2880866428A5033236428 @default.
• W2880866428 hasAuthorship W2880866428A5037185622 @default.
• W2880866428 hasAuthorship W2880866428A5047354338 @default.
• W2880866428 hasAuthorship W2880866428A5075717051 @default.
• W2880866428 hasAuthorship W2880866428A5082864592 @default.
• W2880866428 hasAuthorship W2880866428A5087849258 @default.
• W2880866428 hasBestOaLocation W28808664281 @default.
• W2880866428 hasConcept C104317684 @default.
• W2880866428 hasConcept C119056186 @default.
• W2880866428 hasConcept C181199279 @default.
• W2880866428 hasConcept C185592680 @default.
• W2880866428 hasConcept C203014093 @default.
• W2880866428 hasConcept C2776217839 @default.
• W2880866428 hasConcept C2777723881 @default.
• W2880866428 hasConcept C2779219270 @default.
• W2880866428 hasConcept C2779428903 @default.
• W2880866428 hasConcept C2779730776 @default.
• W2880866428 hasConcept C2780007613 @default.
• W2880866428 hasConcept C502942594 @default.
• W2880866428 hasConcept C55493867 @default.
• W2880866428 hasConcept C86339819 @default.
• W2880866428 hasConcept C86803240 @default.
• W2880866428 hasConcept C88045685 @default.
• W2880866428 hasConcept C95444343 @default.
• W2880866428 hasConceptScore W2880866428C104317684 @default.
• W2880866428 hasConceptScore W2880866428C119056186 @default.
• W2880866428 hasConceptScore W2880866428C181199279 @default.
• W2880866428 hasConceptScore W2880866428C185592680 @default.
• W2880866428 hasConceptScore W2880866428C203014093 @default.

• next