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- W2881096919 endingPage "455" @default.
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- W2881096919 abstract "Both genetic background and environmental factors contribute to primary biliary cholangitis (PBC). Recent innovative technologies, such as genome-wide association studies, identified a remarkable number of susceptible nonhuman leukocyte antigen genes contributing to the development of PBC; however, they are primarily indicators of active immunologic responses commonly involved in autoimmune reactions. Thus, recent studies have focused on epigenetic mechanisms that would link genetic predisposition and environmental triggering factors. In PBC, methylation profiling and altered X chromosome architecture have been intensively explored in conjunction with a striking female predominance. Further, microRNAs have been found to be associated with the etiology of PBC." @default.
- W2881096919 created "2018-07-19" @default.
- W2881096919 creator A5016645912 @default.
- W2881096919 creator A5029678899 @default.
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- W2881096919 date "2018-08-01" @default.
- W2881096919 modified "2023-10-16" @default.
- W2881096919 title "The Genetics and Epigenetics of Primary Biliary Cholangitis" @default.
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- W2881096919 doi "https://doi.org/10.1016/j.cld.2018.03.002" @default.
- W2881096919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259846" @default.
- W2881096919 hasPublicationYear "2018" @default.
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