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- W288202956 abstract "T HE EFFICACY of penicillin for the treatment of gonorrhea is waning. Increasing resistance of the gonococcus to penicillin during the past 20 years has forced escalation of the recommended dofse from 160,000 units to 2,400,000 units for males and 4,800,000 units for females. Sulfonamides were widely used to treat gonorrhea at the end oif the 1930's. Resistance of gonococci to sulfonamides today, however, is so great that by themselves they are no longer useful. We believe it i's essential to try new drugs as the incidence of gonorrhea in the UJnited States continues to increase, and the susceptibility of the gonococcus to penicillin continues to decrease. Minocycline, manufactured by Lederle Laboratories, is composed of 7-dimethylamino-6deoxy-6-dimethyltetracycline. Steigbigel and co-workers (1) stated that average serum concentrations in normal subjects after a single oral dose of 150 mg. or 300 mg. of minocycline were as follows." @default.
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- W288202956 date "1970-01-01" @default.
- W288202956 modified "2023-10-14" @default.
- W288202956 title "Gonorrheal Urethritis in Males Treated with a Single Oral Dose of Minocycline" @default.
- W288202956 cites W1767027717 @default.
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- W288202956 doi "https://doi.org/10.2307/4593816" @default.
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