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- W2883004360 abstract "The overexpression of cyclooxygenase-2 (COX-2) was correlated with the invasion and lymphatic metastasis and with the clinical stage of Nasopharyngeal carcinoma (NPC). The C allele of COX-2 gene rs5275 polymorphism disrupts miR-542-3p function to promote COX-2 overexpression. To examine the role of COX-2 gene rs5275 polymorphism in NPC, we determined COX-2 gene rs5275 polymorphism by using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ Kit. We found that C allele or CC genotype of rs5275 polymorphism in COX-2 gene was associated with an increased risk of NPC. In stratified analyses, COX-2 gene rs5275 polymorphism was associated with the risk of NPC among females, smokers, and drinkers. Based on these results, we concluded that COX-2 gene rs5275 variant contributes to NPC risk in a Chinese population. Larger studies with more diverse ethnic populations are needed to confirm these results." @default.
- W2883004360 created "2018-08-03" @default.
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- W2883004360 date "2018-10-01" @default.
- W2883004360 modified "2023-10-14" @default.
- W2883004360 title "The association between COX-2 gene rs5275 polymorphism and Nasopharyngeal carcinoma risk" @default.
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- W2883004360 doi "https://doi.org/10.1016/j.prp.2018.07.028" @default.
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