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- W2883004954 endingPage "146" @default.
- W2883004954 startingPage "140" @default.
- W2883004954 abstract "Ovarian gap junctions function to provide intercellular communication between ovarian cell types and are critical for proper ovarian function. Connexons are communication channels that are comprised of connexin (CX) proteins. Connexins can be regulated through endocrine signals, thus have dynamic expression throughout the estrous cycle. Not surprisingly, ovarian function is negatively affected in mouse models deficient in Cx genes; loss of Gja4 impairs folliculogenesis while ovaries devoid of Gja1 have reductions in oocyte growth. Chemicals that negatively affect ovarian function, termed ovotoxicants, can directly target Cx mRNA or protein abundance. Endocrine disrupting chemicals, medicinal drugs, pesticides, industrial chemicals, polycyclic aromatic hydrocarbons, recreational drugs and dietary components can affect Cx levels and/or function. Also, aging and obesity can impact ovarian Cx’s. This review highlights what is currently known about ovotoxicant exposures that impact ovarian gap junction function as well as identifies the many gaps in our knowledge in this area of ovarian biology." @default.
- W2883004954 created "2018-08-03" @default.
- W2883004954 creator A5012123704 @default.
- W2883004954 creator A5022643590 @default.
- W2883004954 creator A5078221584 @default.
- W2883004954 date "2018-10-01" @default.
- W2883004954 modified "2023-10-12" @default.
- W2883004954 title "Impact of toxicant exposures on ovarian gap junctions" @default.
- W2883004954 cites W1495114638 @default.
- W2883004954 cites W1534163224 @default.
- W2883004954 cites W1577645380 @default.
- W2883004954 cites W1633726052 @default.
- W2883004954 cites W1881840670 @default.
- W2883004954 cites W1963881210 @default.
- W2883004954 cites W1964564069 @default.
- W2883004954 cites W1968408727 @default.
- W2883004954 cites W1972208841 @default.
- W2883004954 cites W1973690432 @default.
- W2883004954 cites W1979164709 @default.
- W2883004954 cites W1979505989 @default.
- W2883004954 cites W1980238276 @default.
- W2883004954 cites W1982322107 @default.
- W2883004954 cites W1985406943 @default.
- W2883004954 cites W1989988635 @default.
- W2883004954 cites W1991463252 @default.
- W2883004954 cites W1997375207 @default.
- W2883004954 cites W1997592674 @default.
- W2883004954 cites W1999203646 @default.
- W2883004954 cites W2002451073 @default.
- W2883004954 cites W2003164166 @default.
- W2883004954 cites W2008613207 @default.
- W2883004954 cites W2013435542 @default.
- W2883004954 cites W2014105239 @default.
- W2883004954 cites W2017730628 @default.
- W2883004954 cites W2017742298 @default.
- W2883004954 cites W2018581657 @default.
- W2883004954 cites W2018671996 @default.
- W2883004954 cites W2021129636 @default.
- W2883004954 cites W2031938763 @default.
- W2883004954 cites W2035273192 @default.
- W2883004954 cites W2036007437 @default.
- W2883004954 cites W2036777729 @default.
- W2883004954 cites W2040373658 @default.
- W2883004954 cites W2042259903 @default.
- W2883004954 cites W2044641854 @default.
- W2883004954 cites W2061527200 @default.
- W2883004954 cites W2062572677 @default.
- W2883004954 cites W2070969273 @default.
- W2883004954 cites W2071582386 @default.
- W2883004954 cites W2072484890 @default.
- W2883004954 cites W2073417234 @default.
- W2883004954 cites W2075188415 @default.
- W2883004954 cites W2078931335 @default.
- W2883004954 cites W2079326213 @default.
- W2883004954 cites W2081788133 @default.
- W2883004954 cites W2082154626 @default.
- W2883004954 cites W2083493803 @default.
- W2883004954 cites W2088646591 @default.
- W2883004954 cites W2088846045 @default.
- W2883004954 cites W2091185694 @default.
- W2883004954 cites W2092247410 @default.
- W2883004954 cites W2092853998 @default.
- W2883004954 cites W2098299168 @default.
- W2883004954 cites W2100904501 @default.
- W2883004954 cites W2101651255 @default.
- W2883004954 cites W2104225654 @default.
- W2883004954 cites W2105500778 @default.
- W2883004954 cites W2109121993 @default.
- W2883004954 cites W2109606645 @default.
- W2883004954 cites W2112261989 @default.
- W2883004954 cites W2121202274 @default.
- W2883004954 cites W2125849679 @default.
- W2883004954 cites W2126811481 @default.
- W2883004954 cites W2128153936 @default.
- W2883004954 cites W2133092019 @default.
- W2883004954 cites W2135182684 @default.
- W2883004954 cites W2135565236 @default.
- W2883004954 cites W2135637570 @default.
- W2883004954 cites W2136874026 @default.
- W2883004954 cites W2139162788 @default.
- W2883004954 cites W2139740436 @default.
- W2883004954 cites W2152543177 @default.
- W2883004954 cites W2154061913 @default.
- W2883004954 cites W2154410429 @default.
- W2883004954 cites W2154741864 @default.
- W2883004954 cites W2155243157 @default.
- W2883004954 cites W2155573309 @default.
- W2883004954 cites W2161575933 @default.
- W2883004954 cites W2165377719 @default.
- W2883004954 cites W2165796896 @default.
- W2883004954 cites W2167254595 @default.
- W2883004954 cites W2167793553 @default.
- W2883004954 cites W2174133193 @default.
- W2883004954 cites W2210834490 @default.
- W2883004954 cites W2286372733 @default.
- W2883004954 cites W2289903904 @default.
- W2883004954 cites W2406685744 @default.
- W2883004954 cites W2559178581 @default.