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• W2883020951 abstract "Glioblastoma (GBM) is a primary brain tumor with a 5-year survival rate of ≤5%. We have shown earlier that GBM-antibody-linked curcumin (CC) and also phytosomal curcumin (CCP) rescue 50-60% of GBM-bearing mice while repolarizing the tumor-associated microglia/macrophages (TAM) from the tumor-promoting M2-type to the tumoricidal M1-type. However, systemic application of CCP yields only sub-IC50 concentrations of CC in the plasma, which is unlikely to kill GBM cells directly. This study investigates the role of CC-evoked intra-GBM recruitment of activated natural killer (NK) cells in the elimination of GBM and GBM stem cells.We have used an immune-competent syngeneic C57BL6 mouse model with the mouse-GBM GL261 cells orthotopically implanted in the brain. Using immunohistochemistry and flow cytometry, we have quantitatively analyzed the role of the intra-GBM-recruited NK cells by (i) injecting (i.p.) the NK1.1 antibody (NK1.1Ab) to temporarily eliminate the NK cells and (ii) blocking NK recruitment by injecting an IL12 antibody (IL12Ab). The treatment cohorts used randomly-chosen GL261-implanted mice and data sets were compared using two-tailed t-test or ANOVA.CCP treatment caused the GBM tumor to acquire M1-type macrophages (50-60% of the TAM) and activated NK cells. The treatment also elicited (a) suppression of the M2-linked tumor-promoting proteins STAT3, ARG1, and IL10, (b) induction of the M1-linked anti-tumor proteins STAT1 and inducible nitric oxide synthase in the TAM, (c) elimination of CD133(+) GBM stem cells, and (d) activation of caspase3 in the GBM cells. Eliminating intra-GBM NK cell recruitment caused a partial reversal of each of these effects. Concomitantly, we observed a CCP-evoked dramatic induction of the chemokine monocyte chemotactic protein-1 (MCP-1) in the TAM.The recruited NK cells mediate a major part of the CCP-evoked elimination of GBM and GBM stem cells and stabilization of the TAM in the M1-like state. MCP-1 is known to activate peripheral M1-type macrophages to secrete IL12, an activator of NK cells. Based on such observations, we postulate that by binding to peripheral M1-type macrophages and IL12-activated NK cells, the brain-released chemokine MCP-1 causes recruitment of peripheral immune cells into the GBM, thereby causing destruction of the GBM cells and GBM stem cells." @default.
• W2883020951 created "2018-08-03" @default.
• W2883020951 creator A5016765656 @default.
• W2883020951 creator A5050697108 @default.
• W2883020951 creator A5064462400 @default.
• W2883020951 creator A5067616307 @default.
• W2883020951 creator A5067941453 @default.
• W2883020951 creator A5072682382 @default.
• W2883020951 creator A5075612393 @default.
• W2883020951 date "2018-07-25" @default.
• W2883020951 modified "2023-10-15" @default.
• W2883020951 title "Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells" @default.
• W2883020951 cites W1528791634 @default.
• W2883020951 cites W1530715470 @default.
• W2883020951 cites W1546092668 @default.
• W2883020951 cites W1661698621 @default.
• W2883020951 cites W166294487 @default.
• W2883020951 cites W1688195896 @default.
• W2883020951 cites W1782561717 @default.
• W2883020951 cites W1924003041 @default.
• W2883020951 cites W1934310819 @default.
• W2883020951 cites W1943446570 @default.
• W2883020951 cites W1966709711 @default.
• W2883020951 cites W1980021547 @default.
• W2883020951 cites W1983195932 @default.
• W2883020951 cites W1985684774 @default.
• W2883020951 cites W1986679409 @default.
• W2883020951 cites W1989199068 @default.
• W2883020951 cites W1994925991 @default.
• W2883020951 cites W2014135188 @default.
• W2883020951 cites W2017562727 @default.
• W2883020951 cites W2025299523 @default.
• W2883020951 cites W2028556682 @default.
• W2883020951 cites W2032128230 @default.
• W2883020951 cites W2036044314 @default.
• W2883020951 cites W2040459409 @default.
• W2883020951 cites W2044383339 @default.
• W2883020951 cites W2045923059 @default.
• W2883020951 cites W2050070859 @default.
• W2883020951 cites W2050180008 @default.
• W2883020951 cites W2051053191 @default.
• W2883020951 cites W2053523260 @default.
• W2883020951 cites W2053610109 @default.
• W2883020951 cites W2060551076 @default.
• W2883020951 cites W2071079524 @default.
• W2883020951 cites W2074421881 @default.
• W2883020951 cites W2079866862 @default.
• W2883020951 cites W2080789936 @default.
• W2883020951 cites W2082921392 @default.
• W2883020951 cites W2084740946 @default.
• W2883020951 cites W2087814657 @default.
• W2883020951 cites W2091218261 @default.
• W2883020951 cites W2094366129 @default.
• W2883020951 cites W2095569714 @default.
• W2883020951 cites W2096287682 @default.
• W2883020951 cites W2096322385 @default.
• W2883020951 cites W2099171741 @default.
• W2883020951 cites W2099880004 @default.
• W2883020951 cites W2103646648 @default.
• W2883020951 cites W2105364483 @default.
• W2883020951 cites W2105724560 @default.
• W2883020951 cites W2111354523 @default.
• W2883020951 cites W2113518731 @default.
• W2883020951 cites W2116376294 @default.
• W2883020951 cites W2121276929 @default.
• W2883020951 cites W2122191640 @default.
• W2883020951 cites W2125521995 @default.
• W2883020951 cites W2129397604 @default.
• W2883020951 cites W2143062996 @default.
• W2883020951 cites W2143089870 @default.
• W2883020951 cites W2146907709 @default.
• W2883020951 cites W2148216778 @default.
• W2883020951 cites W2151207286 @default.
• W2883020951 cites W2154589271 @default.
• W2883020951 cites W2155099169 @default.
• W2883020951 cites W2156156861 @default.
• W2883020951 cites W2156389657 @default.
• W2883020951 cites W2158649478 @default.
• W2883020951 cites W2159648765 @default.
• W2883020951 cites W2163205164 @default.
• W2883020951 cites W2167017590 @default.
• W2883020951 cites W2167414381 @default.
• W2883020951 cites W2188280766 @default.
• W2883020951 cites W2188757470 @default.
• W2883020951 cites W2209812019 @default.
• W2883020951 cites W2316953565 @default.
• W2883020951 cites W2324360643 @default.
• W2883020951 cites W2328292603 @default.
• W2883020951 cites W2345568581 @default.
• W2883020951 cites W2407797794 @default.
• W2883020951 cites W2415914925 @default.
• W2883020951 cites W2511897228 @default.
• W2883020951 cites W2515424042 @default.
• W2883020951 cites W2548210940 @default.
• W2883020951 cites W2559816317 @default.
• W2883020951 cites W2560367415 @default.
• W2883020951 cites W2587486634 @default.
• W2883020951 cites W2588102465 @default.
• W2883020951 cites W2616418042 @default.
• W2883020951 cites W2788291716 @default.

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