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- W2883030306 abstract "Abstract Morphology together with the capability to respond to surrounding stimuli are key elements governing the spatial interaction of living cells with the environment. In this respect, biomechanical stimulation can trigger significant physiological cascades that can potentially modulate toxicity. Deoxynivalenol (DON, vomitoxin) is one of the most prevalent mycotoxins produced by Fusarium spp. and it was used to explore the delicate interaction between biomechanical stimulation and cytotoxicity in A431 cells. In fact, in addition of being a food contaminant, DON is a relevant toxin for several organ systems. The combination between biomechanical stimulation and the mycotoxin revealed how DON can impair crucial functions affecting cellular morphology, tubulin and lysosomes at concentrations even below those known to be cytotoxic in routine toxicity studies. Sub-toxic concentrations of DON (0.1–1 μM) impaired the capability of A431 cells to respond to a biomechanical stimulation that normally sustains trophic effects in these cells. Moreover, the effects of DON (0.1–10 μM) were partially modulated by the application of uniaxial stretching (0.5 Hz, 24 h, 15% deformation). Ultimately, proteomic analysis revealed the potential of DON to alter several proteins necessary for cell adhesion and cytoskeletal modulation suggesting a molecular link between biomechanics and the cytotoxic potential of the mycotoxin." @default.
- W2883030306 created "2018-08-03" @default.
- W2883030306 creator A5003951356 @default.
- W2883030306 creator A5030182453 @default.
- W2883030306 creator A5035889786 @default.
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- W2883030306 creator A5037895834 @default.
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- W2883030306 creator A5039475936 @default.
- W2883030306 creator A5075467201 @default.
- W2883030306 creator A5089561414 @default.
- W2883030306 date "2018-07-27" @default.
- W2883030306 modified "2023-10-14" @default.
- W2883030306 title "Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation" @default.
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