FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883035258> ?p ?o ?g. }

• W2883035258 endingPage "237" @default.
• W2883035258 startingPage "227" @default.
• W2883035258 abstract "Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. To discern the molecular heterogeneity within PFB, we performed an integrated analysis consisting of DNA methylation profiling, copy-number profiling, gene expression profiling, and clinical correlation across a cohort of 212 primary posterior fossa PFB tumors. Unsupervised spectral clustering and t-SNE analysis of genome-wide methylation data revealed five distinct subtypes of PFB tumors, termed PFB1-5, with distinct demographics, copy-number alterations, and gene expression profiles. All PFB subtypes were distinct from PFA and posterior fossa subependymomas. Of the five subtypes, PFB4 and PFB5 are more discrete, consisting of younger and older patients, respectively, with a strong female-gender enrichment in PFB5 (age: p = 0.011, gender: p = 0.04). Broad copy-number aberrations were common; however, many events such as chromosome 2 loss, 5 gain, and 17 loss were enriched in specific subtypes and 1q gain was enriched in PFB1. Late relapses were common across all five subtypes, but deaths were uncommon and present in only two subtypes (PFB1 and PFB3). Unlike the case in PFA ependymoma, 1q gain was not a robust marker of poor progression-free survival; however, chromosome 13q loss may represent a novel marker for risk stratification across the spectrum of PFB subtypes. Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified. Even when accounting for this heterogeneity, extent of resection remains the strongest predictor of poor outcome. However, this biological heterogeneity must be accounted for in future preclinical modeling and personalized therapies." @default.
• W2883035258 created "2018-08-03" @default.
• W2883035258 creator A5003000553 @default.
• W2883035258 creator A5005241979 @default.
• W2883035258 creator A5005329272 @default.
• W2883035258 creator A5006930070 @default.
• W2883035258 creator A5007528270 @default.
• W2883035258 creator A5008096194 @default.
• W2883035258 creator A5010939758 @default.
• W2883035258 creator A5012407631 @default.
• W2883035258 creator A5013759067 @default.
• W2883035258 creator A5019028542 @default.
• W2883035258 creator A5021379896 @default.
• W2883035258 creator A5022310517 @default.
• W2883035258 creator A5022651335 @default.
• W2883035258 creator A5029794929 @default.
• W2883035258 creator A5030214712 @default.
• W2883035258 creator A5034087578 @default.
• W2883035258 creator A5035101546 @default.
• W2883035258 creator A5038035447 @default.
• W2883035258 creator A5039750788 @default.
• W2883035258 creator A5041096535 @default.
• W2883035258 creator A5041913264 @default.
• W2883035258 creator A5043001715 @default.
• W2883035258 creator A5043812430 @default.
• W2883035258 creator A5045697502 @default.
• W2883035258 creator A5046828105 @default.
• W2883035258 creator A5047816589 @default.
• W2883035258 creator A5050160345 @default.
• W2883035258 creator A5055167599 @default.
• W2883035258 creator A5056698189 @default.
• W2883035258 creator A5056872026 @default.
• W2883035258 creator A5059000453 @default.
• W2883035258 creator A5060494950 @default.
• W2883035258 creator A5063290790 @default.
• W2883035258 creator A5064627876 @default.
• W2883035258 creator A5067228740 @default.
• W2883035258 creator A5068257880 @default.
• W2883035258 creator A5068751821 @default.
• W2883035258 creator A5069689120 @default.
• W2883035258 creator A5070917396 @default.
• W2883035258 creator A5071632296 @default.
• W2883035258 creator A5071966341 @default.
• W2883035258 creator A5073211182 @default.
• W2883035258 creator A5073862375 @default.
• W2883035258 creator A5074092540 @default.
• W2883035258 creator A5074904937 @default.
• W2883035258 creator A5075152654 @default.
• W2883035258 creator A5075358445 @default.
• W2883035258 creator A5077068981 @default.
• W2883035258 creator A5078181843 @default.
• W2883035258 creator A5078400193 @default.
• W2883035258 creator A5078567170 @default.
• W2883035258 creator A5082372397 @default.
• W2883035258 creator A5083530167 @default.
• W2883035258 creator A5089877146 @default.
• W2883035258 creator A5090815387 @default.
• W2883035258 creator A5091009354 @default.
• W2883035258 creator A5091712536 @default.
• W2883035258 date "2018-07-17" @default.
• W2883035258 modified "2023-10-11" @default.
• W2883035258 title "Heterogeneity within the PF-EPN-B ependymoma subgroup" @default.
• W2883035258 cites W1949037014 @default.
• W2883035258 cites W1971349026 @default.
• W2883035258 cites W2070262236 @default.
• W2883035258 cites W2113432767 @default.
• W2883035258 cites W2115610792 @default.
• W2883035258 cites W2122404743 @default.
• W2883035258 cites W2129504986 @default.
• W2883035258 cites W2140048538 @default.
• W2883035258 cites W2143619463 @default.
• W2883035258 cites W2145489645 @default.
• W2883035258 cites W2171236756 @default.
• W2883035258 cites W2293420365 @default.
• W2883035258 cites W2413224284 @default.
• W2883035258 cites W2516200712 @default.
• W2883035258 cites W2549263597 @default.
• W2883035258 cites W2553451383 @default.
• W2883035258 cites W2555606007 @default.
• W2883035258 cites W2603695299 @default.
• W2883035258 cites W2626440326 @default.
• W2883035258 cites W2627021459 @default.
• W2883035258 cites W2768707078 @default.
• W2883035258 cites W2780843582 @default.
• W2883035258 cites W2787816121 @default.
• W2883035258 cites W2807973758 @default.
• W2883035258 cites W2918086501 @default.
• W2883035258 cites W45534775 @default.
• W2883035258 doi "https://doi.org/10.1007/s00401-018-1888-x" @default.
• W2883035258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6373486" @default.
• W2883035258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30019219" @default.
• W2883035258 hasPublicationYear "2018" @default.
• W2883035258 type Work @default.
• W2883035258 sameAs 2883035258 @default.
• W2883035258 citedByCount "78" @default.
• W2883035258 countsByYear W28830352582018 @default.
• W2883035258 countsByYear W28830352582019 @default.
• W2883035258 countsByYear W28830352582020 @default.

• next