FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883043285> ?p ?o ?g. }

• W2883043285 endingPage "2866" @default.
• W2883043285 startingPage "2860" @default.
• W2883043285 abstract "To compare the efficacy of pre-emptive versus empirical antifungal therapy in children with cancer, fever and neutropenia. This was a prospective, multicentre, randomized clinical trial. Children presenting with persistent high-risk febrile neutropenia at five hospitals in Santiago, Chile, were randomized to empirical or pre-emptive antifungal therapy. The pre-emptive group received antifungal therapy only if the persistent high-risk febrile neutropenia was accompanied by clinical, laboratory, imaging or microbiological pre-defined criteria. The primary endpoint was overall mortality at day 30 of follow-up. Secondary endpoints included invasive fungal disease (IFD)-related mortality, number of days of fever, days of hospitalization and use of antifungal drugs, percentage of children developing IFD, requiring modification of initial treatment strategy and need for ICU. The trial was registered with Registro Brasileiro de Ensaios Clínicos (ReBEC) under trial number RBR-3m9d74. A total of 149 children were randomized, 73 to empirical therapy and 76 to pre-emptive therapy. Thirty-two out of 76 (42%) children in the pre-emptive group received antifungal therapy. The median duration of antifungal therapy was 11 days in the empirical arm and 6 days in the pre-emptive arm (P < 0.001), with similar overall mortality (8% in the empirical arm and 5% in the pre-emptive arm, P = 0.47). IFD-related mortality was the same in both groups (3%, P = 0.97), as were the percentage of children with IFD (12%, P = 0.92) and the number of days of fever (9, P = 0.76). The number of days of hospitalization was 19 in the empirical arm and 17 in the pre-emptive arm (P = 0.15) and the need for ICU was 25% in the empirical arm and 20% in the pre-emptive arm (P = 0.47). Pre-emptive antifungal therapy was as effective as empirical antifungal therapy in children with cancer, fever and neutropenia, significantly reducing the use of antifungal drugs." @default.
• W2883043285 created "2018-08-03" @default.
• W2883043285 creator A5001557357 @default.
• W2883043285 creator A5005501706 @default.
• W2883043285 creator A5017963202 @default.
• W2883043285 creator A5021550828 @default.
• W2883043285 creator A5024130170 @default.
• W2883043285 creator A5024481748 @default.
• W2883043285 creator A5026014319 @default.
• W2883043285 creator A5026149623 @default.
• W2883043285 creator A5027127020 @default.
• W2883043285 creator A5055768614 @default.
• W2883043285 creator A5059549851 @default.
• W2883043285 creator A5081602016 @default.
• W2883043285 creator A5082973085 @default.
• W2883043285 creator A5083981444 @default.
• W2883043285 creator A5089290431 @default.
• W2883043285 date "2018-07-13" @default.
• W2883043285 modified "2023-10-06" @default.
• W2883043285 title "Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia: a randomized clinical trial" @default.
• W2883043285 cites W1892067584 @default.
• W2883043285 cites W1978332231 @default.
• W2883043285 cites W1997758641 @default.
• W2883043285 cites W1998688570 @default.
• W2883043285 cites W2004228729 @default.
• W2883043285 cites W2016958989 @default.
• W2883043285 cites W2039266307 @default.
• W2883043285 cites W2072356889 @default.
• W2883043285 cites W2072711373 @default.
• W2883043285 cites W2090373867 @default.
• W2883043285 cites W2106555097 @default.
• W2883043285 cites W2107683308 @default.
• W2883043285 cites W2109770581 @default.
• W2883043285 cites W2115832986 @default.
• W2883043285 cites W2116440163 @default.
• W2883043285 cites W2122633716 @default.
• W2883043285 cites W2126982929 @default.
• W2883043285 cites W2149002422 @default.
• W2883043285 cites W2150641305 @default.
• W2883043285 cites W2152583091 @default.
• W2883043285 cites W2154085372 @default.
• W2883043285 cites W2166734004 @default.
• W2883043285 cites W2170388896 @default.
• W2883043285 cites W2174981249 @default.
• W2883043285 cites W2515258867 @default.
• W2883043285 cites W2515429879 @default.
• W2883043285 cites W2563079954 @default.
• W2883043285 cites W2610889635 @default.
• W2883043285 doi "https://doi.org/10.1093/jac/dky244" @default.
• W2883043285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30010931" @default.
• W2883043285 hasPublicationYear "2018" @default.
• W2883043285 type Work @default.
• W2883043285 sameAs 2883043285 @default.
• W2883043285 citedByCount "35" @default.
• W2883043285 countsByYear W28830432852018 @default.
• W2883043285 countsByYear W28830432852019 @default.
• W2883043285 countsByYear W28830432852020 @default.
• W2883043285 countsByYear W28830432852021 @default.
• W2883043285 countsByYear W28830432852022 @default.
• W2883043285 countsByYear W28830432852023 @default.
• W2883043285 crossrefType "journal-article" @default.
• W2883043285 hasAuthorship W2883043285A5001557357 @default.
• W2883043285 hasAuthorship W2883043285A5005501706 @default.
• W2883043285 hasAuthorship W2883043285A5017963202 @default.
• W2883043285 hasAuthorship W2883043285A5021550828 @default.
• W2883043285 hasAuthorship W2883043285A5024130170 @default.
• W2883043285 hasAuthorship W2883043285A5024481748 @default.
• W2883043285 hasAuthorship W2883043285A5026014319 @default.
• W2883043285 hasAuthorship W2883043285A5026149623 @default.
• W2883043285 hasAuthorship W2883043285A5027127020 @default.
• W2883043285 hasAuthorship W2883043285A5055768614 @default.
• W2883043285 hasAuthorship W2883043285A5059549851 @default.
• W2883043285 hasAuthorship W2883043285A5081602016 @default.
• W2883043285 hasAuthorship W2883043285A5082973085 @default.
• W2883043285 hasAuthorship W2883043285A5083981444 @default.
• W2883043285 hasAuthorship W2883043285A5089290431 @default.
• W2883043285 hasBestOaLocation W28830432851 @default.
• W2883043285 hasConcept C126322002 @default.
• W2883043285 hasConcept C168563851 @default.
• W2883043285 hasConcept C203092338 @default.
• W2883043285 hasConcept C2776694085 @default.
• W2883043285 hasConcept C2777063308 @default.
• W2883043285 hasConcept C2778850193 @default.
• W2883043285 hasConcept C71924100 @default.
• W2883043285 hasConceptScore W2883043285C126322002 @default.
• W2883043285 hasConceptScore W2883043285C168563851 @default.
• W2883043285 hasConceptScore W2883043285C203092338 @default.
• W2883043285 hasConceptScore W2883043285C2776694085 @default.
• W2883043285 hasConceptScore W2883043285C2777063308 @default.
• W2883043285 hasConceptScore W2883043285C2778850193 @default.
• W2883043285 hasConceptScore W2883043285C71924100 @default.
• W2883043285 hasFunder F4320338073 @default.
• W2883043285 hasIssue "10" @default.
• W2883043285 hasLocation W28830432851 @default.
• W2883043285 hasLocation W28830432852 @default.
• W2883043285 hasOpenAccess W2883043285 @default.
• W2883043285 hasPrimaryLocation W28830432851 @default.
• W2883043285 hasRelatedWork W1638203718 @default.

• next