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• W2883047514 abstract "Background: Inflamed gastric mucosa is the hallmark of gastric pathologies such as gastritis, gastric ulcer and gastric cancer. Helicobacter pylori infection is most commonly associated with diseased epithelium mainly due to strong T helper cell type 1 immune response. Therefore it can be assumed that an effective antimicrobial substance with the capability of modulating Th1 response might be an effective therapeutic regime. In this study, we assessed the effect of natural edible substances such as green tea, sea buckthorn, raspberry, cranberry, elderberry, strawberry, bilberry, blueberry on H. pylori associated host immune response. Methods & Materials: Aqueous food extracts and their combinations were first tested for antimicrobial property against Helicobacter pylori 49503 (a toxin-producing strain known to be associated with gastric cancer) by agar dilution method. We further tested there on cytotoxicity, H. pylori infectivity and immunomodulatory effects on cytokine profile of H. pylori infected human gastric adenocarcinoma cells (MKN-45). Results: Berry extracts exhibited antimicrobial activity alone (MIC 1 mg/ml) and in combination of metronidazole. Metronidazole combination, however do not improve concentrations of food extract required to inhibit bacterial growth. No bacterial inhibition was found when green tea was used alone but its presence with metronidazole enhanced drug activity. Food extracts were able to up-regulate expression of Th2 cytokine genes. Berry extracts enhanced the expression of IL-1, IL-4, IL-10 and IL-21. In contrast, gene expression of Th1 profile was significantly downregulated with an apparent emphasis on IL12β, IL-8 and IFN-γ. Significant increase in IL-1, IL-4 and IFN-γ levels was found higher after green tea treatment. The infectivity of gastric cells with H. pylori was compromised at sub-inhibitory drug levels. Conclusion: Our data suggests the significant role of food extracts in the control of Helicobacter pylori induced gastritis. Direct antimicrobial effect contributes in the eradication of infection and down regulation of IL-8, particularly because of edible berries might decrease the intensity of Th1 derived damage of gastric mucosa. Increased expression of Th2 genes might help in retrieving Th1/Th2 balance in inflamed gastric cells accompanied H. pylori infection. Green tea might not be anti-Helicobacter but has potential to deviate inflamed gastric environment that indirectly impact on Helicobacter pylori infection." @default.
• W2883047514 created "2018-08-03" @default.
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• W2883047514 date "2018-08-01" @default.
• W2883047514 modified "2023-10-06" @default.
• W2883047514 title "Reversion of Th1/Th2 cytokine imbalance in gastric mucosa impact on infectivity of Helicobacter pylori" @default.
• W2883047514 doi "https://doi.org/10.1016/j.ijid.2018.04.3679" @default.
• W2883047514 hasPublicationYear "2018" @default.
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