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- W2883057888 abstract "Piracetam, 2-Oxy-1-pyrrolidine Acetamide is a cyclic derivative of gamma-aminobutyric acid. This agent has recently been shown to have activity in humans as a platelet suppressant. For the prophylaxis of recurrent deep venous thrombosis (RDVT), many clinicians are now resorting to antiplatelet agents, rather than vitamin K antagonist because of the questionable efficacy and severe bleeding associated with these latter agents. The most common antiplatelet agents used for prophylaxis of RDVT are ASA, dipyridamole, and sulfinpyrazone given alone or in various combinations. The purpose of this study was to assess the efficacy of Piracetam as an antiplatelet agent for the prophylaxis of RDVT. Twenty patients with a history of RDVT or with active DVT were entered into the trial; 10 of these were randomized to a combination of ASA (600 mg. BID) + Dipyridamole (50 mg QID) and 10 were randomized to Piracetam at 9.6 gm/day as 2.4 gm QID. Pre-ingestion evaluation included a complete history and physical and complete evaluation of hemostasis including PT, PTT, FDP, PSO4, AT- III, platelet adhesion, platelet aggregation, PF-4, and platelet survival by sizing. Follow-up evaluation was performed at 6 weeks, 3 mo., and 6 mo. All patients demonstrated a laboratory response to antiplatelet therapy as manifest by aggregation and PF-4 studies, all patients on Piracetam and most patients in the other group demonstrated improvement in platelet survival studies. During the six month observation, no patients ingesting Piracetam developed rethrombosis; however, two patients ingesting ASA/Dipyridamole relapsed. These results suggest Piracetam to be equal to and possibly superior to ASA/Dipyridamole in preventing RDVT. In view of this efficacy together with lack of toxicity Piracetam may prove highly useful as a clinically effective antiplatelet agent in the prophylaxis of RDVT." @default.
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- W2883057888 date "1981-01-01" @default.
- W2883057888 modified "2023-10-13" @default.
- W2883057888 title "The Effect Of Piracetam In Preventing Recurrent Deep Venous Thrombosis" @default.
- W2883057888 doi "https://doi.org/10.1055/s-0038-1652224" @default.
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