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- W2883080885 abstract "Notch signaling research dates back to more than one hundred years, beginning with the identification of the Notch mutant in the fruit fly Drosophila melanogaster. Since then, research on Notch and related genes in flies has laid the foundation of what we now know as the Notch signaling pathway. In the 1990s, basic biological and biochemical studies of Notch signaling components in mammalian systems, as well as identification of rare mutations in Notch signaling pathway genes in human patients with rare Mendelian diseases or cancer, increased the significance of this pathway in human biology and medicine. In the 21st century, Drosophila and other genetic model organisms continue to play a leading role in understanding basic Notch biology. Furthermore, these model organisms can be used in a translational manner to study underlying mechanisms of Notch-related human diseases and to investigate the function of novel disease associated genes and variants. In this chapter, we first briefly review the major contributions of Drosophila to Notch signaling research, discussing the similarities and differences between the fly and human pathways. Next, we introduce several biological contexts in Drosophila in which Notch signaling has been extensively characterized. Finally, we discuss a number of genetic diseases caused by mutations in genes in the Notch signaling pathway in humans and we expand on how Drosophila can be used to study rare genetic variants associated with these and novel disorders. By combining modern genomics and state-of-the art technologies, Drosophila research is continuing to reveal exciting biology that sheds light onto mechanisms of disease." @default.
- W2883080885 created "2018-08-03" @default.
- W2883080885 creator A5057632716 @default.
- W2883080885 creator A5081429488 @default.
- W2883080885 date "2018-01-01" @default.
- W2883080885 modified "2023-10-05" @default.
- W2883080885 title "Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases" @default.
- W2883080885 cites W1466378854 @default.
- W2883080885 cites W1481214469 @default.
- W2883080885 cites W1482735025 @default.
- W2883080885 cites W1483357513 @default.
- W2883080885 cites W1488427743 @default.
- W2883080885 cites W1496266131 @default.
- W2883080885 cites W1501421306 @default.
- W2883080885 cites W1504123405 @default.
- W2883080885 cites W1507734204 @default.
- W2883080885 cites W1508615665 @default.
- W2883080885 cites W1515731519 @default.
- W2883080885 cites W1532104480 @default.
- W2883080885 cites W1542949307 @default.
- W2883080885 cites W1543633454 @default.
- W2883080885 cites W1548290904 @default.
- W2883080885 cites W1550560980 @default.
- W2883080885 cites W1552559843 @default.
- W2883080885 cites W1566528879 @default.
- W2883080885 cites W1566623998 @default.
- W2883080885 cites W1572790640 @default.
- W2883080885 cites W1573111276 @default.
- W2883080885 cites W1574918102 @default.
- W2883080885 cites W1579881301 @default.
- W2883080885 cites W1584239726 @default.
- W2883080885 cites W159146810 @default.
- W2883080885 cites W1595935608 @default.
- W2883080885 cites W1597435584 @default.
- W2883080885 cites W1606899363 @default.
- W2883080885 cites W1625373986 @default.
- W2883080885 cites W1639210574 @default.
- W2883080885 cites W1651448739 @default.
- W2883080885 cites W1655397332 @default.
- W2883080885 cites W1701211704 @default.
- W2883080885 cites W1790815665 @default.
- W2883080885 cites W1791584368 @default.
- W2883080885 cites W1795830070 @default.
- W2883080885 cites W1815642178 @default.
- W2883080885 cites W1824693654 @default.
- W2883080885 cites W1826046671 @default.
- W2883080885 cites W1839893894 @default.
- W2883080885 cites W1844615320 @default.
- W2883080885 cites W1844917473 @default.
- W2883080885 cites W1849009517 @default.
- W2883080885 cites W1849390150 @default.
- W2883080885 cites W1858921550 @default.
- W2883080885 cites W1871729829 @default.
- W2883080885 cites W1885556853 @default.
- W2883080885 cites W1898057624 @default.
- W2883080885 cites W1912953907 @default.
- W2883080885 cites W1919664558 @default.
- W2883080885 cites W1921203043 @default.
- W2883080885 cites W1921966622 @default.
- W2883080885 cites W1923882567 @default.
- W2883080885 cites W1926625721 @default.
- W2883080885 cites W1927705215 @default.
- W2883080885 cites W1933869586 @default.
- W2883080885 cites W1941799095 @default.
- W2883080885 cites W1964077949 @default.
- W2883080885 cites W1966296397 @default.
- W2883080885 cites W1966398860 @default.
- W2883080885 cites W1966735021 @default.
- W2883080885 cites W1967051571 @default.
- W2883080885 cites W1967115518 @default.
- W2883080885 cites W1967192173 @default.
- W2883080885 cites W1967281511 @default.
- W2883080885 cites W1968343429 @default.
- W2883080885 cites W1970447649 @default.
- W2883080885 cites W1970492716 @default.
- W2883080885 cites W1971571526 @default.
- W2883080885 cites W1972289087 @default.
- W2883080885 cites W1973049378 @default.
- W2883080885 cites W1973569665 @default.
- W2883080885 cites W1973618536 @default.
- W2883080885 cites W1974185766 @default.
- W2883080885 cites W1975236596 @default.
- W2883080885 cites W1975561755 @default.
- W2883080885 cites W1976207845 @default.
- W2883080885 cites W1976257234 @default.
- W2883080885 cites W1976390169 @default.
- W2883080885 cites W1976646890 @default.
- W2883080885 cites W1976686299 @default.
- W2883080885 cites W1976777120 @default.
- W2883080885 cites W1977474446 @default.
- W2883080885 cites W1977661665 @default.
- W2883080885 cites W1977748972 @default.
- W2883080885 cites W1977962361 @default.
- W2883080885 cites W1978979379 @default.
- W2883080885 cites W1979458365 @default.
- W2883080885 cites W1980595514 @default.
- W2883080885 cites W1981116235 @default.
- W2883080885 cites W1981563641 @default.