FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883093721> ?p ?o ?g. }

• W2883093721 endingPage "205" @default.
• W2883093721 startingPage "197" @default.
• W2883093721 abstract "Background: Preeclampsia, a serious pregnancy-associated syndrome, is the leading cause of maternal and perinatal morbidity and mortality. Significant exacerbation of the hypercoagulation status as well as imbalanced steroid hormones have been reported in developed preeclampsia. However, it remains unclear whether the two pathological changes are directly associated. Method and results: Our proteomic analysis revealed a significantly elevated SerpinF2/α2-antiplasmin level in preeclampsia plasma. Measurement of the longitudinally gestational change of plasmin-α2-antiplasmin (PAP) complex, testosterone, estradiol in preeclampsia patients and normal pregnant women demonstrated that the circulating PAP and testosterone levels in the early-onset preeclampsia (E-PE) patients were substantially higher, whereas estradiol concentration was significantly lower than that in normal pregnant controls from early pregnancy throughout gestation. Correlation analysis revealed that circulating PAP is in positive correlation with the concentration of testosterone, and in negative correlation with estradiol in E-PE patients. In E-PE placenta, the productions and activities of 17β-hydroxysteroid dehydrogenases 3 and aromatase, the essential enzymes for testosterone and estradiol synthesis, were compromised. In human renal and trophoblastic cells, testosterone and estradiol could regulate SerpinF2 expression in opposite ways. In addition, obvious fibrin deposition was colocalized with SerpinF2 in intervillous spaces and the area surrounding syncytiotrophoblasts in E-PE placenta. Conclusion: The findings reveal a tight correlation between the imbalanced steroid hormone production and the procoagulation factor in E-PE patients, which provide potential biomarkers to predict preeclampsia, and bring new insight into the pathogenesis of preeclampsia." @default.
• W2883093721 created "2018-08-03" @default.
• W2883093721 creator A5005329167 @default.
• W2883093721 creator A5006680675 @default.
• W2883093721 creator A5019056174 @default.
• W2883093721 creator A5035687681 @default.
• W2883093721 creator A5036240291 @default.
• W2883093721 creator A5047604705 @default.
• W2883093721 creator A5049086579 @default.
• W2883093721 creator A5050760975 @default.
• W2883093721 creator A5058972118 @default.
• W2883093721 creator A5066829203 @default.
• W2883093721 creator A5074537749 @default.
• W2883093721 creator A5078587480 @default.
• W2883093721 creator A5085174219 @default.
• W2883093721 date "2019-01-01" @default.
• W2883093721 modified "2023-10-06" @default.
• W2883093721 title "Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia" @default.
• W2883093721 cites W1480938058 @default.
• W2883093721 cites W1900839667 @default.
• W2883093721 cites W1966168394 @default.
• W2883093721 cites W1974551635 @default.
• W2883093721 cites W1975133011 @default.
• W2883093721 cites W1975414081 @default.
• W2883093721 cites W1980330982 @default.
• W2883093721 cites W1983127023 @default.
• W2883093721 cites W2004144070 @default.
• W2883093721 cites W2009911043 @default.
• W2883093721 cites W2011784685 @default.
• W2883093721 cites W2013920248 @default.
• W2883093721 cites W2023946767 @default.
• W2883093721 cites W2030378494 @default.
• W2883093721 cites W2035426088 @default.
• W2883093721 cites W2037892337 @default.
• W2883093721 cites W2041194471 @default.
• W2883093721 cites W2064702510 @default.
• W2883093721 cites W2073243174 @default.
• W2883093721 cites W2099021486 @default.
• W2883093721 cites W2116030405 @default.
• W2883093721 cites W2120194957 @default.
• W2883093721 cites W2138411886 @default.
• W2883093721 cites W2145141579 @default.
• W2883093721 cites W2153047557 @default.
• W2883093721 cites W2156933633 @default.
• W2883093721 cites W2170906400 @default.
• W2883093721 cites W2176215908 @default.
• W2883093721 cites W2201095422 @default.
• W2883093721 cites W2338134821 @default.
• W2883093721 cites W2346642200 @default.
• W2883093721 cites W2893645357 @default.
• W2883093721 cites W4211203631 @default.
• W2883093721 doi "https://doi.org/10.1097/hjh.0000000000001862" @default.
• W2883093721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30020241" @default.
• W2883093721 hasPublicationYear "2019" @default.
• W2883093721 type Work @default.
• W2883093721 sameAs 2883093721 @default.
• W2883093721 citedByCount "14" @default.
• W2883093721 countsByYear W28830937212019 @default.
• W2883093721 countsByYear W28830937212020 @default.
• W2883093721 countsByYear W28830937212021 @default.
• W2883093721 countsByYear W28830937212022 @default.
• W2883093721 countsByYear W28830937212023 @default.
• W2883093721 crossrefType "journal-article" @default.
• W2883093721 hasAuthorship W2883093721A5005329167 @default.
• W2883093721 hasAuthorship W2883093721A5006680675 @default.
• W2883093721 hasAuthorship W2883093721A5019056174 @default.
• W2883093721 hasAuthorship W2883093721A5035687681 @default.
• W2883093721 hasAuthorship W2883093721A5036240291 @default.
• W2883093721 hasAuthorship W2883093721A5047604705 @default.
• W2883093721 hasAuthorship W2883093721A5049086579 @default.
• W2883093721 hasAuthorship W2883093721A5050760975 @default.
• W2883093721 hasAuthorship W2883093721A5058972118 @default.
• W2883093721 hasAuthorship W2883093721A5066829203 @default.
• W2883093721 hasAuthorship W2883093721A5074537749 @default.
• W2883093721 hasAuthorship W2883093721A5078587480 @default.
• W2883093721 hasAuthorship W2883093721A5085174219 @default.
• W2883093721 hasConcept C126322002 @default.
• W2883093721 hasConcept C134018914 @default.
• W2883093721 hasConcept C172680121 @default.
• W2883093721 hasConcept C2776953305 @default.
• W2883093721 hasConcept C2777164284 @default.
• W2883093721 hasConcept C2777218350 @default.
• W2883093721 hasConcept C2779234561 @default.
• W2883093721 hasConcept C2779279991 @default.
• W2883093721 hasConcept C2780942790 @default.
• W2883093721 hasConcept C2908795334 @default.
• W2883093721 hasConcept C46973012 @default.
• W2883093721 hasConcept C54355233 @default.
• W2883093721 hasConcept C71315377 @default.
• W2883093721 hasConcept C71924100 @default.
• W2883093721 hasConcept C86803240 @default.
• W2883093721 hasConceptScore W2883093721C126322002 @default.
• W2883093721 hasConceptScore W2883093721C134018914 @default.
• W2883093721 hasConceptScore W2883093721C172680121 @default.
• W2883093721 hasConceptScore W2883093721C2776953305 @default.
• W2883093721 hasConceptScore W2883093721C2777164284 @default.
• W2883093721 hasConceptScore W2883093721C2777218350 @default.
• W2883093721 hasConceptScore W2883093721C2779234561 @default.

• next