FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883120010> ?p ?o ?g. }

• W2883120010 endingPage "575" @default.
• W2883120010 startingPage "557" @default.
• W2883120010 abstract "Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background This study tested the hypothesis that ad lib running wheel exercise in a tibia fracture model of complex regional pain syndrome can reverse hindlimb nociceptive sensitization and inflammation in mice. Methods Three weeks after tibia fracture, the cast was removed and hindlimb von Frey thresholds and unweighting were tested; the mice were then randomized to either ad lib access to a running wheel for 4 weeks or no wheel access. After 4 weeks the behavioral testing was repeated and then skin, sciatic nerve, and spinal cord tissues collected for polymerase chain reaction and enzyme immunoassay measurements of neuropeptide and inflammatory mediator levels. A similar protocol was used in fracture mice treated with exercise for 4 weeks, and then the running wheel was removed for 2 weeks. Memory and anxiety were measured in both groups with use of open-field, zero-maze, and novel-objects recognition assays. Results At 7 weeks postfracture the mice with no wheel access exhibited hindlimb allodynia and unweighting, anxiety, memory loss, upregulated spinal neuropeptide signaling, and increased hind paw and spinal inflammatory mediator expression, but the postfracture mice allowed to exercise for 4 weeks exhibited none of these changes (n = 12/cohort). When exercise was stopped for 2 weeks after 4 weeks of running, hindlimb allodynia and unweighting were rekindled, and this nociceptive sensitization was associated with increased sciatic nerve neuropeptide levels and hind paw skin interleukin 6 and nerve growth factor expression (n = 12/cohort). Conclusions Daily exercise reversed nociceptive sensitization, inflammation, anxiety, and memory loss after tibia fracture." @default.
• W2883120010 created "2018-08-03" @default.
• W2883120010 creator A5017701312 @default.
• W2883120010 creator A5048023375 @default.
• W2883120010 creator A5049621128 @default.
• W2883120010 creator A5056384169 @default.
• W2883120010 creator A5061565879 @default.
• W2883120010 creator A5068488754 @default.
• W2883120010 creator A5069008709 @default.
• W2883120010 creator A5072565784 @default.
• W2883120010 date "2018-09-01" @default.
• W2883120010 modified "2023-10-01" @default.
• W2883120010 title "Exercise Reverses Nociceptive Sensitization, Upregulated Neuropeptide Signaling, Inflammatory Changes, Anxiety, and Memory Impairment in a Mouse Tibia Fracture Model" @default.
• W2883120010 cites W1652577435 @default.
• W2883120010 cites W1892003845 @default.
• W2883120010 cites W1966037459 @default.
• W2883120010 cites W1972810592 @default.
• W2883120010 cites W1976024859 @default.
• W2883120010 cites W1981481422 @default.
• W2883120010 cites W1981912417 @default.
• W2883120010 cites W1985734972 @default.
• W2883120010 cites W1987637078 @default.
• W2883120010 cites W1990726115 @default.
• W2883120010 cites W1997819076 @default.
• W2883120010 cites W2001308670 @default.
• W2883120010 cites W2007085082 @default.
• W2883120010 cites W2012701523 @default.
• W2883120010 cites W2015724541 @default.
• W2883120010 cites W2020674432 @default.
• W2883120010 cites W2023834445 @default.
• W2883120010 cites W2024032885 @default.
• W2883120010 cites W2024434614 @default.
• W2883120010 cites W2048934895 @default.
• W2883120010 cites W2054595878 @default.
• W2883120010 cites W2057188974 @default.
• W2883120010 cites W2061915937 @default.
• W2883120010 cites W2070561438 @default.
• W2883120010 cites W2076593192 @default.
• W2883120010 cites W2076649598 @default.
• W2883120010 cites W2080049061 @default.
• W2883120010 cites W2105594333 @default.
• W2883120010 cites W2108978334 @default.
• W2883120010 cites W2122398729 @default.
• W2883120010 cites W2131607858 @default.
• W2883120010 cites W2150458942 @default.
• W2883120010 cites W2150708673 @default.
• W2883120010 cites W2152686904 @default.
• W2883120010 cites W2156648641 @default.
• W2883120010 cites W2158413216 @default.
• W2883120010 cites W2161668911 @default.
• W2883120010 cites W2162638563 @default.
• W2883120010 cites W2163345643 @default.
• W2883120010 cites W2275274326 @default.
• W2883120010 cites W2338471643 @default.
• W2883120010 cites W2412551333 @default.
• W2883120010 cites W2520457704 @default.
• W2883120010 cites W2521627406 @default.
• W2883120010 cites W2586547866 @default.
• W2883120010 cites W2727856545 @default.
• W2883120010 cites W2753059628 @default.
• W2883120010 cites W55539597 @default.
• W2883120010 cites W903328313 @default.
• W2883120010 doi "https://doi.org/10.1097/aln.0000000000002332" @default.
• W2883120010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6092202" @default.
• W2883120010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29994924" @default.
• W2883120010 hasPublicationYear "2018" @default.
• W2883120010 type Work @default.
• W2883120010 sameAs 2883120010 @default.
• W2883120010 citedByCount "23" @default.
• W2883120010 countsByYear W28831200102019 @default.
• W2883120010 countsByYear W28831200102020 @default.
• W2883120010 countsByYear W28831200102021 @default.
• W2883120010 countsByYear W28831200102022 @default.
• W2883120010 countsByYear W28831200102023 @default.
• W2883120010 crossrefType "journal-article" @default.
• W2883120010 hasAuthorship W2883120010A5017701312 @default.
• W2883120010 hasAuthorship W2883120010A5048023375 @default.
• W2883120010 hasAuthorship W2883120010A5049621128 @default.
• W2883120010 hasAuthorship W2883120010A5056384169 @default.
• W2883120010 hasAuthorship W2883120010A5061565879 @default.
• W2883120010 hasAuthorship W2883120010A5068488754 @default.
• W2883120010 hasAuthorship W2883120010A5069008709 @default.
• W2883120010 hasAuthorship W2883120010A5072565784 @default.
• W2883120010 hasBestOaLocation W28831200102 @default.
• W2883120010 hasConcept C118303440 @default.
• W2883120010 hasConcept C126322002 @default.
• W2883120010 hasConcept C134018914 @default.
• W2883120010 hasConcept C141071460 @default.
• W2883120010 hasConcept C15490471 @default.
• W2883120010 hasConcept C170493617 @default.
• W2883120010 hasConcept C203014093 @default.
• W2883120010 hasConcept C2776217527 @default.
• W2883120010 hasConcept C2777236700 @default.
• W2883120010 hasConcept C2777883359 @default.
• W2883120010 hasConcept C2779245659 @default.
• W2883120010 hasConcept C2781149210 @default.
• W2883120010 hasConcept C2910052784 @default.
• W2883120010 hasConcept C42219234 @default.

• next