FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883138051> ?p ?o ?g. }

• W2883138051 endingPage "e0200768" @default.
• W2883138051 startingPage "e0200768" @default.
• W2883138051 abstract "Recent studies showed that induced microRNA-449a (miR-449a) enhances a G2/M cell cycle checkpoint arrest in prostate cancer (LNCaP) and lung adenocarcinoma cell lines. In the case of LNCaP cells, upregulated miR-449a directly downregulates c-Myc that is required to induce the cell cycle regulators Cdc25A and Cdc2/CyclinB whose inactivation blocks G2 to M phase transition. However, the molecular mechanisms involved are yet unclear, although in other prostate cancer cells the interactions among p53, miR-449a and Sirt-1 can affect the induction of the G2/M arrest. In order to clarify these molecular mechanisms, in this work we propose a boolean model of the G2/M checkpoint arrest regulation contemplating the influence of miR-449a. The model shows that the cell fate determination between two cellular phenotypes: G2/M-Arrest for DNA repair and G2/M-induced apoptosis is stochastic and influenced by miR-449a state of activation. The results were compared with experimental data available presenting agreement. We also found that several feedback loops are involved in this cell fate regulation and we indicate, through in silico gain or loss of function perturbations of genes, which of these feedback loops are more efficient to favor a specific phenotype." @default.
• W2883138051 created "2018-08-03" @default.
• W2883138051 creator A5000081923 @default.
• W2883138051 creator A5033025455 @default.
• W2883138051 creator A5049678192 @default.
• W2883138051 date "2018-07-19" @default.
• W2883138051 modified "2023-09-26" @default.
• W2883138051 title "Modeling the role of microRNA-449a in the regulation of the G2/M cell cycle checkpoint in prostate LNCaP cells under ionizing radiation" @default.
• W2883138051 cites W1495729285 @default.
• W2883138051 cites W1950559180 @default.
• W2883138051 cites W1984143603 @default.
• W2883138051 cites W1986512406 @default.
• W2883138051 cites W2016492849 @default.
• W2883138051 cites W2055087351 @default.
• W2883138051 cites W2058223290 @default.
• W2883138051 cites W2058631780 @default.
• W2883138051 cites W2063669247 @default.
• W2883138051 cites W2073531000 @default.
• W2883138051 cites W2092529541 @default.
• W2883138051 cites W2095324538 @default.
• W2883138051 cites W2102752109 @default.
• W2883138051 cites W2105841205 @default.
• W2883138051 cites W2123356446 @default.
• W2883138051 cites W2128252882 @default.
• W2883138051 cites W2132935366 @default.
• W2883138051 cites W2133290549 @default.
• W2883138051 cites W2139710924 @default.
• W2883138051 cites W2152750766 @default.
• W2883138051 cites W2157727263 @default.
• W2883138051 cites W2173477184 @default.
• W2883138051 cites W2190400042 @default.
• W2883138051 cites W2262294211 @default.
• W2883138051 cites W2330936054 @default.
• W2883138051 cites W2436013910 @default.
• W2883138051 cites W2472023498 @default.
• W2883138051 cites W2625337179 @default.
• W2883138051 doi "https://doi.org/10.1371/journal.pone.0200768" @default.
• W2883138051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6053189" @default.
• W2883138051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30024932" @default.
• W2883138051 hasPublicationYear "2018" @default.
• W2883138051 type Work @default.
• W2883138051 sameAs 2883138051 @default.
• W2883138051 citedByCount "18" @default.
• W2883138051 countsByYear W28831380512019 @default.
• W2883138051 countsByYear W28831380512020 @default.
• W2883138051 countsByYear W28831380512021 @default.
• W2883138051 countsByYear W28831380512022 @default.
• W2883138051 countsByYear W28831380512023 @default.
• W2883138051 crossrefType "journal-article" @default.
• W2883138051 hasAuthorship W2883138051A5000081923 @default.
• W2883138051 hasAuthorship W2883138051A5033025455 @default.
• W2883138051 hasAuthorship W2883138051A5049678192 @default.
• W2883138051 hasBestOaLocation W28831380511 @default.
• W2883138051 hasConcept C104317684 @default.
• W2883138051 hasConcept C105696609 @default.
• W2883138051 hasConcept C121608353 @default.
• W2883138051 hasConcept C143425029 @default.
• W2883138051 hasConcept C145059251 @default.
• W2883138051 hasConcept C1491633281 @default.
• W2883138051 hasConcept C2777228722 @default.
• W2883138051 hasConcept C2779723316 @default.
• W2883138051 hasConcept C2780192828 @default.
• W2883138051 hasConcept C29537977 @default.
• W2883138051 hasConcept C502942594 @default.
• W2883138051 hasConcept C54355233 @default.
• W2883138051 hasConcept C552990157 @default.
• W2883138051 hasConcept C86803240 @default.
• W2883138051 hasConcept C95444343 @default.
• W2883138051 hasConceptScore W2883138051C104317684 @default.
• W2883138051 hasConceptScore W2883138051C105696609 @default.
• W2883138051 hasConceptScore W2883138051C121608353 @default.
• W2883138051 hasConceptScore W2883138051C143425029 @default.
• W2883138051 hasConceptScore W2883138051C145059251 @default.
• W2883138051 hasConceptScore W2883138051C1491633281 @default.
• W2883138051 hasConceptScore W2883138051C2777228722 @default.
• W2883138051 hasConceptScore W2883138051C2779723316 @default.
• W2883138051 hasConceptScore W2883138051C2780192828 @default.
• W2883138051 hasConceptScore W2883138051C29537977 @default.
• W2883138051 hasConceptScore W2883138051C502942594 @default.
• W2883138051 hasConceptScore W2883138051C54355233 @default.
• W2883138051 hasConceptScore W2883138051C552990157 @default.
• W2883138051 hasConceptScore W2883138051C86803240 @default.
• W2883138051 hasConceptScore W2883138051C95444343 @default.
• W2883138051 hasFunder F4320321091 @default.
• W2883138051 hasFunder F4320322025 @default.
• W2883138051 hasIssue "7" @default.
• W2883138051 hasLocation W28831380511 @default.
• W2883138051 hasLocation W28831380512 @default.
• W2883138051 hasLocation W28831380513 @default.
• W2883138051 hasLocation W28831380514 @default.
• W2883138051 hasLocation W28831380515 @default.
• W2883138051 hasLocation W28831380516 @default.
• W2883138051 hasOpenAccess W2883138051 @default.
• W2883138051 hasPrimaryLocation W28831380511 @default.
• W2883138051 hasRelatedWork W1903281146 @default.
• W2883138051 hasRelatedWork W1977497204 @default.
• W2883138051 hasRelatedWork W2027931017 @default.
• W2883138051 hasRelatedWork W2029878748 @default.

• next