FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883147421> ?p ?o ?g. }

• W2883147421 endingPage "8371" @default.
• W2883147421 startingPage "8362" @default.
• W2883147421 abstract "The use of emerging nanotechnologies, such as plasmonic nanoparticles in diagnostic applications, potentially offers opportunities to revolutionize disease management and patient healthcare. Despite worldwide research efforts in this area, there is still a dearth of nanodiagnostics which have been successfully translated for real-world patient usage due to the predominant sole focus on assay analytical performance and lack of detailed investigations into clinical performance in human samples. In a bid to address this pressing need, we herein describe a comprehensive clinical verification of a prospective label-free surface-enhanced Raman scattering (SERS) nanodiagnostic assay for prostate cancer (PCa) risk stratification. This contribution depicts a roadmap of (1) designing a SERS assay for robust and accurate detection of clinically validated PCa RNA targets; (2) employing a relevant and proven PCa clinical biomarker model to test our nanodiagnostic assay; and (3) investigating the clinical performance on independent training ( n = 80) and validation ( n = 40) cohorts of PCa human patient samples. By relating the detection outcomes to gold-standard patient biopsy findings, we established a PCa risk scoring system which exhibited a clinical sensitivity and specificity of 0.87 and 0.90, respectively [area-under-curve of 0.84 (95% confidence interval: 0.81-0.87) for differentiating high- and low-risk PCa] in the validation cohort. We envision that our SERS nanodiagnostic design and clinical verification approach may aid in the individualized prediction of PCa presence and risk stratification and may overall serve as an archetypical strategy to encourage comprehensive clinical evaluation of nanodiagnostic innovations." @default.
• W2883147421 created "2018-08-03" @default.
• W2883147421 creator A5005026253 @default.
• W2883147421 creator A5030459168 @default.
• W2883147421 creator A5032243347 @default.
• W2883147421 creator A5034554281 @default.
• W2883147421 creator A5037677450 @default.
• W2883147421 creator A5039344852 @default.
• W2883147421 creator A5045527532 @default.
• W2883147421 creator A5046333945 @default.
• W2883147421 creator A5047900211 @default.
• W2883147421 creator A5049856226 @default.
• W2883147421 creator A5050374698 @default.
• W2883147421 creator A5062046621 @default.
• W2883147421 creator A5064622840 @default.
• W2883147421 creator A5086310893 @default.
• W2883147421 date "2018-07-20" @default.
• W2883147421 modified "2023-10-09" @default.
• W2883147421 title "Design and Clinical Verification of Surface-Enhanced Raman Spectroscopy Diagnostic Technology for Individual Cancer Risk Prediction" @default.
• W2883147421 cites W1561712812 @default.
• W2883147421 cites W1573867559 @default.
• W2883147421 cites W1855078567 @default.
• W2883147421 cites W1970592466 @default.
• W2883147421 cites W1979349240 @default.
• W2883147421 cites W1981818407 @default.
• W2883147421 cites W1989201384 @default.
• W2883147421 cites W2020210187 @default.
• W2883147421 cites W2091998550 @default.
• W2883147421 cites W2097876373 @default.
• W2883147421 cites W2100073570 @default.
• W2883147421 cites W2112044462 @default.
• W2883147421 cites W2154821684 @default.
• W2883147421 cites W2160870426 @default.
• W2883147421 cites W2171001108 @default.
• W2883147421 cites W2263455747 @default.
• W2883147421 cites W2272966210 @default.
• W2883147421 cites W2328480348 @default.
• W2883147421 cites W2387415489 @default.
• W2883147421 cites W2474334896 @default.
• W2883147421 cites W2478418883 @default.
• W2883147421 cites W2514767475 @default.
• W2883147421 cites W2527231564 @default.
• W2883147421 cites W2560292269 @default.
• W2883147421 cites W2588197532 @default.
• W2883147421 cites W2588918392 @default.
• W2883147421 cites W2598084316 @default.
• W2883147421 cites W2743742601 @default.
• W2883147421 cites W2748987862 @default.
• W2883147421 cites W2966258052 @default.
• W2883147421 doi "https://doi.org/10.1021/acsnano.8b03698" @default.
• W2883147421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30028592" @default.
• W2883147421 hasPublicationYear "2018" @default.
• W2883147421 type Work @default.
• W2883147421 sameAs 2883147421 @default.
• W2883147421 citedByCount "61" @default.
• W2883147421 countsByYear W28831474212018 @default.
• W2883147421 countsByYear W28831474212019 @default.
• W2883147421 countsByYear W28831474212020 @default.
• W2883147421 countsByYear W28831474212021 @default.
• W2883147421 countsByYear W28831474212022 @default.
• W2883147421 countsByYear W28831474212023 @default.
• W2883147421 crossrefType "journal-article" @default.
• W2883147421 hasAuthorship W2883147421A5005026253 @default.
• W2883147421 hasAuthorship W2883147421A5030459168 @default.
• W2883147421 hasAuthorship W2883147421A5032243347 @default.
• W2883147421 hasAuthorship W2883147421A5034554281 @default.
• W2883147421 hasAuthorship W2883147421A5037677450 @default.
• W2883147421 hasAuthorship W2883147421A5039344852 @default.
• W2883147421 hasAuthorship W2883147421A5045527532 @default.
• W2883147421 hasAuthorship W2883147421A5046333945 @default.
• W2883147421 hasAuthorship W2883147421A5047900211 @default.
• W2883147421 hasAuthorship W2883147421A5049856226 @default.
• W2883147421 hasAuthorship W2883147421A5050374698 @default.
• W2883147421 hasAuthorship W2883147421A5062046621 @default.
• W2883147421 hasAuthorship W2883147421A5064622840 @default.
• W2883147421 hasAuthorship W2883147421A5086310893 @default.
• W2883147421 hasBestOaLocation W28831474212 @default.
• W2883147421 hasConcept C119857082 @default.
• W2883147421 hasConcept C120665830 @default.
• W2883147421 hasConcept C121332964 @default.
• W2883147421 hasConcept C121608353 @default.
• W2883147421 hasConcept C12174686 @default.
• W2883147421 hasConcept C126322002 @default.
• W2883147421 hasConcept C143998085 @default.
• W2883147421 hasConcept C154945302 @default.
• W2883147421 hasConcept C169573571 @default.
• W2883147421 hasConcept C185592680 @default.
• W2883147421 hasConcept C19527891 @default.
• W2883147421 hasConcept C2777790068 @default.
• W2883147421 hasConcept C2780192828 @default.
• W2883147421 hasConcept C2781197716 @default.
• W2883147421 hasConcept C3020404979 @default.
• W2883147421 hasConcept C38652104 @default.
• W2883147421 hasConcept C40003534 @default.
• W2883147421 hasConcept C40993552 @default.
• W2883147421 hasConcept C41008148 @default.
• W2883147421 hasConcept C44249647 @default.
• W2883147421 hasConcept C535046627 @default.

• next