FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883149569> ?p ?o ?g. }

• W2883149569 endingPage "418" @default.
• W2883149569 startingPage "403" @default.
• W2883149569 abstract "Being advertised and distributed as attractive substitutes of cannabis, synthetic cannabinoids (SC) are gaining increasing relevance in forensic and clinical toxicology. As no data from controlled human studies are available, SC are sold and consumed without the knowledge of their toxicokinetic (TK) and toxicodynamic properties. Hence, animal models coupled with mathematical approaches should be used to ascertain those properties. Therefore, a controlled pig TK study allowing for extrapolation to human data was performed. For this purpose, eleven pigs received a single pulmonary dose of 200 µg/kg body weight each of Δ9-tetrahydrocannabinol (THC), 4-ethylnaphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-210) as well as 2-(4-methoxyphenyl)-1-(1-pentyl-indole-3-yl)methanone (RCS-4) via an ultrasonic nebulizer. Blood and urine samples were repeatedly drawn over 8 h. Serum-concentration-time profiles of the parent compounds were determined using LC-MS/MS. Urine specimens were analyzed by LC-HR-MS/MS in order to elucidate the main metabolites. Maximum serum concentrations were reached 10–15 min after beginning of nebulization and amounted to 66 ± 36 ng/mL for THC, 41 ± 11 ng/mL for JWH-210, and 34 ± 8.9 ng/mL for RCS-4. The serum-concentration-time profiles of THC, JWH-210, and RCS-4 were best described by three-compartment models with first order absorption and elimination processes. Absorption from the lungs to serum was modeled by first-order processes. The determination of the bioavailability yielded 23.0%, 24.2%, and 45.7% for THC, JWH-210, and RCS-4, respectively. Furthermore, the developed THC model was upscaled to humans using allometric scaling techniques. A successful prediction of human concentration-time profiles could be done. Also the metabolic patterns were in good agreement with human data. In conclusion, these findings are the first reported regarding the TK properties of SC after pulmonary administration to pigs. The presented method of TK serves as an appropriate predictor of human TK of cannabinoids." @default.
• W2883149569 created "2018-08-03" @default.
• W2883149569 creator A5002844010 @default.
• W2883149569 creator A5005967499 @default.
• W2883149569 creator A5006881744 @default.
• W2883149569 creator A5023070415 @default.
• W2883149569 creator A5034709401 @default.
• W2883149569 creator A5037739081 @default.
• W2883149569 creator A5037819335 @default.
• W2883149569 creator A5080845006 @default.
• W2883149569 creator A5086293908 @default.
• W2883149569 creator A5091020854 @default.
• W2883149569 date "2018-09-01" @default.
• W2883149569 modified "2023-09-27" @default.
• W2883149569 title "Can toxicokinetics of (synthetic) cannabinoids in pigs after pulmonary administration be upscaled to humans by allometric techniques?" @default.
• W2883149569 cites W1175366871 @default.
• W2883149569 cites W1899248520 @default.
• W2883149569 cites W1970059344 @default.
• W2883149569 cites W1974457902 @default.
• W2883149569 cites W1976087389 @default.
• W2883149569 cites W1981251493 @default.
• W2883149569 cites W1982611995 @default.
• W2883149569 cites W1983417139 @default.
• W2883149569 cites W2006583270 @default.
• W2883149569 cites W2011730107 @default.
• W2883149569 cites W2011859517 @default.
• W2883149569 cites W2018943943 @default.
• W2883149569 cites W2020125001 @default.
• W2883149569 cites W2024053795 @default.
• W2883149569 cites W2031904744 @default.
• W2883149569 cites W2033341227 @default.
• W2883149569 cites W2053434964 @default.
• W2883149569 cites W2069838009 @default.
• W2883149569 cites W2074114778 @default.
• W2883149569 cites W2082913382 @default.
• W2883149569 cites W2084088153 @default.
• W2883149569 cites W2088615500 @default.
• W2883149569 cites W2091333188 @default.
• W2883149569 cites W2098430390 @default.
• W2883149569 cites W2099909319 @default.
• W2883149569 cites W2104637562 @default.
• W2883149569 cites W2112208186 @default.
• W2883149569 cites W2116555823 @default.
• W2883149569 cites W2119895547 @default.
• W2883149569 cites W2121604669 @default.
• W2883149569 cites W2129536608 @default.
• W2883149569 cites W2132394707 @default.
• W2883149569 cites W2163954214 @default.
• W2883149569 cites W2166480531 @default.
• W2883149569 cites W2168249179 @default.
• W2883149569 cites W2169754532 @default.
• W2883149569 cites W2171503950 @default.
• W2883149569 cites W2232881761 @default.
• W2883149569 cites W2330617626 @default.
• W2883149569 cites W2345293717 @default.
• W2883149569 cites W2460104600 @default.
• W2883149569 cites W2522590875 @default.
• W2883149569 cites W2558627160 @default.
• W2883149569 cites W2602464333 @default.
• W2883149569 cites W2786070257 @default.
• W2883149569 cites W4243414587 @default.
• W2883149569 cites W974037284 @default.
• W2883149569 doi "https://doi.org/10.1016/j.bcp.2018.07.029" @default.
• W2883149569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30048626" @default.
• W2883149569 hasPublicationYear "2018" @default.
• W2883149569 type Work @default.
• W2883149569 sameAs 2883149569 @default.
• W2883149569 citedByCount "9" @default.
• W2883149569 countsByYear W28831495692019 @default.
• W2883149569 countsByYear W28831495692020 @default.
• W2883149569 countsByYear W28831495692021 @default.
• W2883149569 countsByYear W28831495692022 @default.
• W2883149569 crossrefType "journal-article" @default.
• W2883149569 hasAuthorship W2883149569A5002844010 @default.
• W2883149569 hasAuthorship W2883149569A5005967499 @default.
• W2883149569 hasAuthorship W2883149569A5006881744 @default.
• W2883149569 hasAuthorship W2883149569A5023070415 @default.
• W2883149569 hasAuthorship W2883149569A5034709401 @default.
• W2883149569 hasAuthorship W2883149569A5037739081 @default.
• W2883149569 hasAuthorship W2883149569A5037819335 @default.
• W2883149569 hasAuthorship W2883149569A5080845006 @default.
• W2883149569 hasAuthorship W2883149569A5086293908 @default.
• W2883149569 hasAuthorship W2883149569A5091020854 @default.
• W2883149569 hasConcept C112705442 @default.
• W2883149569 hasConcept C121332964 @default.
• W2883149569 hasConcept C125287762 @default.
• W2883149569 hasConcept C170493617 @default.
• W2883149569 hasConcept C181389837 @default.
• W2883149569 hasConcept C185592680 @default.
• W2883149569 hasConcept C195289149 @default.
• W2883149569 hasConcept C19749203 @default.
• W2883149569 hasConcept C24890656 @default.
• W2883149569 hasConcept C2777846614 @default.
• W2883149569 hasConcept C2780026642 @default.
• W2883149569 hasConcept C2780871563 @default.
• W2883149569 hasConcept C2908858883 @default.
• W2883149569 hasConcept C33070731 @default.
• W2883149569 hasConcept C43617362 @default.

• next