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- W2883152670 abstract "In humans, schizophrenia with onset in adolescence or adult has distinct features. To understand whether schizophrenia with either adolescence- or adult-onset have distinct phenotypes and cellular mechanisms in schizophrenia model mice, we altered Nrg1 signaling during either adolescence or adult mice via injection of anti-Nrg1 antibodies. We found that in either early-onset schizophrenia (EOS)- or late-onset schizophrenia (LOS)-like mice, certain behavior phenotypes are shared including hyperlocomotion, impaired working memory and impaired fear conditioning. Anxiety appears to be largely unaffected. In vitro electrophysiology in brain slices showed altered excitation/inhibition balance in EOS-like mice towards enhanced synaptic excitation, but intrinsic excitability of the fast-spiking GABAergic neurons was elevated in the LOS-like mice. Thus, although schizophrenia-like main phenotypes appear to be preserved in both age onset model mice, there are distinct differences in cellular mechanisms between them. We suggest that these differences are important for more precise diagnosis and more effective treatment of schizophrenia." @default.
- W2883152670 created "2018-08-03" @default.
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- W2883152670 creator A5038043249 @default.
- W2883152670 creator A5058555426 @default.
- W2883152670 creator A5088845373 @default.
- W2883152670 date "2019-03-01" @default.
- W2883152670 modified "2023-10-16" @default.
- W2883152670 title "Effect of age onset on schizophrenia-like phenotypes and underlying mechanisms in model mice" @default.
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- W2883152670 doi "https://doi.org/10.1016/j.pnpbp.2018.07.015" @default.
- W2883152670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30025793" @default.
- W2883152670 hasPublicationYear "2019" @default.
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