Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883157404> ?p ?o ?g. }
- W2883157404 abstract "Acute kidney injury (AKI) is a hyper-inflammation-induced abrupt loss of kidney function and has become a major public health problem. The cecal ligation and puncture (CLP) model of peritonitis in rat pups mimics the development of sepsis-induced pediatric AKI is pre-renal without morphological changes of the kidneys and high lethality. Resveratrol, a natural polyphenolic compound with low toxicity, has obvious anti-oxidant and anti-inflammatory properties. The present study aimed to determine whether resveratrol alleviates pediatric AKI and investigated the potential mechanism. Thus, a CLP model of 17-18 day-old rat pups was used to mimic the development of sepsis-induced AKI in children. In the group treated with resveratrol, renal injury induced by CLP was alleviated with downregulation of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and kidney injury molecule (KIM)-1 expression. Nuclear factor-erythroid-2-related factor 2 (Nrf2) signaling is known to effectively inhibit inflammation, the present study found that resveratrol reduced the lipopolysaccharide-induced inflammatory response in kidney cells in vitro and induced the activation of Nrf2 signaling, including accumulation of nuclear Nrf2 and increase of the expression of Nrf2 target genes heme oxygenase (HO)-1 and NAD(P)H dehydrogenase (quinone) 1 (NQO1); this was confirmed by the induction of the expression of HO-1 and NQO1 by treatment of resveratrol in vitro and in vivo. Of note, knockdown of Nrf2 effectively abrogated the downregulation of TNF-α, IL-1β and KIM-1 expression induced by resveratrol in vitro. These results suggested that resveratrol ameliorates sepsis-induced acute kidney injury in a pediatric model of AKI via the Nrf2 signaling pathway." @default.
- W2883157404 created "2018-08-03" @default.
- W2883157404 creator A5003642180 @default.
- W2883157404 creator A5014953889 @default.
- W2883157404 creator A5033629741 @default.
- W2883157404 creator A5081759576 @default.
- W2883157404 creator A5085328469 @default.
- W2883157404 date "2018-07-27" @default.
- W2883157404 modified "2023-10-17" @default.
- W2883157404 title "Resveratrol ameliorates sepsis‑induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway" @default.
- W2883157404 cites W1971799714 @default.
- W2883157404 cites W1971865201 @default.
- W2883157404 cites W1972556189 @default.
- W2883157404 cites W1972852504 @default.
- W2883157404 cites W1974525446 @default.
- W2883157404 cites W1990886132 @default.
- W2883157404 cites W2003144827 @default.
- W2883157404 cites W2007032123 @default.
- W2883157404 cites W2018038176 @default.
- W2883157404 cites W2019433277 @default.
- W2883157404 cites W2021690806 @default.
- W2883157404 cites W2030447619 @default.
- W2883157404 cites W2032304585 @default.
- W2883157404 cites W2037066133 @default.
- W2883157404 cites W2044542888 @default.
- W2883157404 cites W2045421375 @default.
- W2883157404 cites W2048246530 @default.
- W2883157404 cites W2052455413 @default.
- W2883157404 cites W2052559630 @default.
- W2883157404 cites W2052708460 @default.
- W2883157404 cites W2064452102 @default.
- W2883157404 cites W2071726718 @default.
- W2883157404 cites W2075685041 @default.
- W2883157404 cites W2088220499 @default.
- W2883157404 cites W2094413238 @default.
- W2883157404 cites W2096261918 @default.
- W2883157404 cites W2107277218 @default.
- W2883157404 cites W2110175104 @default.
- W2883157404 cites W2125551755 @default.
- W2883157404 cites W2142405038 @default.
- W2883157404 cites W2153059926 @default.
- W2883157404 cites W2154111720 @default.
- W2883157404 cites W2162666750 @default.
- W2883157404 cites W2164321693 @default.
- W2883157404 cites W2167682953 @default.
- W2883157404 cites W2192080449 @default.
- W2883157404 cites W2613483874 @default.
- W2883157404 cites W2620241325 @default.
- W2883157404 doi "https://doi.org/10.3892/etm.2018.6533" @default.
- W2883157404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125985" @default.
- W2883157404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30214546" @default.
- W2883157404 hasPublicationYear "2018" @default.
- W2883157404 type Work @default.
- W2883157404 sameAs 2883157404 @default.
- W2883157404 citedByCount "18" @default.
- W2883157404 countsByYear W28831574042019 @default.
- W2883157404 countsByYear W28831574042020 @default.
- W2883157404 countsByYear W28831574042021 @default.
- W2883157404 countsByYear W28831574042022 @default.
- W2883157404 countsByYear W28831574042023 @default.
- W2883157404 crossrefType "journal-article" @default.
- W2883157404 hasAuthorship W2883157404A5003642180 @default.
- W2883157404 hasAuthorship W2883157404A5014953889 @default.
- W2883157404 hasAuthorship W2883157404A5033629741 @default.
- W2883157404 hasAuthorship W2883157404A5081759576 @default.
- W2883157404 hasAuthorship W2883157404A5085328469 @default.
- W2883157404 hasBestOaLocation W28831574041 @default.
- W2883157404 hasConcept C104317684 @default.
- W2883157404 hasConcept C126322002 @default.
- W2883157404 hasConcept C127561419 @default.
- W2883157404 hasConcept C17991360 @default.
- W2883157404 hasConcept C181199279 @default.
- W2883157404 hasConcept C203014093 @default.
- W2883157404 hasConcept C2776217839 @default.
- W2883157404 hasConcept C2776816829 @default.
- W2883157404 hasConcept C2776914184 @default.
- W2883157404 hasConcept C2778384902 @default.
- W2883157404 hasConcept C2779219270 @default.
- W2883157404 hasConcept C2780091579 @default.
- W2883157404 hasConcept C2780472472 @default.
- W2883157404 hasConcept C502942594 @default.
- W2883157404 hasConcept C55493867 @default.
- W2883157404 hasConcept C71924100 @default.
- W2883157404 hasConcept C86803240 @default.
- W2883157404 hasConcept C98274493 @default.
- W2883157404 hasConceptScore W2883157404C104317684 @default.
- W2883157404 hasConceptScore W2883157404C126322002 @default.
- W2883157404 hasConceptScore W2883157404C127561419 @default.
- W2883157404 hasConceptScore W2883157404C17991360 @default.
- W2883157404 hasConceptScore W2883157404C181199279 @default.
- W2883157404 hasConceptScore W2883157404C203014093 @default.
- W2883157404 hasConceptScore W2883157404C2776217839 @default.
- W2883157404 hasConceptScore W2883157404C2776816829 @default.
- W2883157404 hasConceptScore W2883157404C2776914184 @default.
- W2883157404 hasConceptScore W2883157404C2778384902 @default.
- W2883157404 hasConceptScore W2883157404C2779219270 @default.
- W2883157404 hasConceptScore W2883157404C2780091579 @default.
- W2883157404 hasConceptScore W2883157404C2780472472 @default.
- W2883157404 hasConceptScore W2883157404C502942594 @default.
- W2883157404 hasConceptScore W2883157404C55493867 @default.