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- W2883170783 abstract "Abstract Dendrimers are nanostructured ‘architectural motifs’ with a well‐tailored polymeric structure, symmetric tree‐like shape and the presence of several functional groups and inner cavities, and are of eminent interest in many biomedical applications such as drug delivery, gene transfection and imaging. In the work reported, reliable protocols for the synthesis of polyester‐based, hydrolysable, amphiphilic polycationic dendrimers were developed. A C‐18 hydrocarbon chain provided by a biocompatible fatty acid, stearic acid, and second‐ and third‐generation dendrons based on 2,2‐bis(hydroxymethyl)propionic acid were built on 2,2‐bis(hydroxymethyl)propanol and pentaerythritol as core molecules. α N ‐BOC‐ ω' N ‐(NO 2 )‐ l ‐arginine alone, mixed with α N , ϵ N ‐di‐BOC‐ l ‐lysine or also with N , N ′‐dimethylglycine and α N ‐BOC‐methylglycine were successfully bound to the prepared polyester neutral scaffolds and, after the removal of protecting groups, five cationic dendrimers were obtained. Their structure was confirmed using NMR analysis and experimental molecular weight. Their buffer capacity, comparable to that of polyethyleneimines, was optimal, high viability percentage values were obtained from cytotoxicity assays and zeta potential and mean particle size were in the desired ranges. The synthesized nanostructured compounds that harmonize a multifunctional polycationic shell, a biodegradable uncharged polyester matrix and a C‐18 hydrophobic portion helpful for an improved hydrophilic–lipophilic balance in their structure embody all the fundamental features to be suitable for biomedical applications. © 2018 Society of Chemical Industry" @default.
- W2883170783 created "2018-08-03" @default.
- W2883170783 creator A5042110354 @default.
- W2883170783 creator A5059689447 @default.
- W2883170783 date "2018-08-24" @default.
- W2883170783 modified "2023-10-14" @default.
- W2883170783 title "Synthesis and characterization of versatile amphiphilic dendrimers peripherally decorated with positively charged amino acids" @default.
- W2883170783 cites W1796155527 @default.
- W2883170783 cites W187505281 @default.
- W2883170783 cites W1963992284 @default.
- W2883170783 cites W1965231344 @default.
- W2883170783 cites W1968481792 @default.
- W2883170783 cites W1972890442 @default.
- W2883170783 cites W1973021352 @default.
- W2883170783 cites W1977512696 @default.
- W2883170783 cites W1977891655 @default.
- W2883170783 cites W1987366690 @default.
- W2883170783 cites W1988554418 @default.
- W2883170783 cites W1993845520 @default.
- W2883170783 cites W1994333466 @default.
- W2883170783 cites W1997547574 @default.
- W2883170783 cites W1997664422 @default.
- W2883170783 cites W1998697301 @default.
- W2883170783 cites W1998891630 @default.
- W2883170783 cites W1999808218 @default.
- W2883170783 cites W2000289996 @default.
- W2883170783 cites W2000586035 @default.
- W2883170783 cites W2002903271 @default.
- W2883170783 cites W2003414091 @default.
- W2883170783 cites W2004994771 @default.
- W2883170783 cites W2008971936 @default.
- W2883170783 cites W2009500363 @default.
- W2883170783 cites W2010542051 @default.
- W2883170783 cites W2011226972 @default.
- W2883170783 cites W2013875806 @default.
- W2883170783 cites W2018032428 @default.
- W2883170783 cites W2018707728 @default.
- W2883170783 cites W2024532144 @default.
- W2883170783 cites W2027762479 @default.
- W2883170783 cites W2029380542 @default.
- W2883170783 cites W2029697829 @default.
- W2883170783 cites W2033335822 @default.
- W2883170783 cites W2035192891 @default.
- W2883170783 cites W2037817748 @default.
- W2883170783 cites W2038720383 @default.
- W2883170783 cites W2044477424 @default.
- W2883170783 cites W2045723738 @default.
- W2883170783 cites W2049213756 @default.
- W2883170783 cites W2053495654 @default.
- W2883170783 cites W2058490945 @default.
- W2883170783 cites W2059502455 @default.
- W2883170783 cites W2062224149 @default.
- W2883170783 cites W2069761655 @default.
- W2883170783 cites W2073296825 @default.
- W2883170783 cites W2075402079 @default.
- W2883170783 cites W2080387639 @default.
- W2883170783 cites W2080823739 @default.
- W2883170783 cites W2085146994 @default.
- W2883170783 cites W2088467380 @default.
- W2883170783 cites W2088654227 @default.
- W2883170783 cites W2089006322 @default.
- W2883170783 cites W2090135401 @default.
- W2883170783 cites W2091417143 @default.
- W2883170783 cites W2091892090 @default.
- W2883170783 cites W2109276789 @default.
- W2883170783 cites W2114612952 @default.
- W2883170783 cites W2117890573 @default.
- W2883170783 cites W2118618046 @default.
- W2883170783 cites W2119962654 @default.
- W2883170783 cites W2146670754 @default.
- W2883170783 cites W2154675426 @default.
- W2883170783 cites W2162029104 @default.
- W2883170783 cites W2162826264 @default.
- W2883170783 cites W2209620742 @default.
- W2883170783 cites W2262070131 @default.
- W2883170783 cites W2316320201 @default.
- W2883170783 cites W2325199377 @default.
- W2883170783 cites W2395546188 @default.
- W2883170783 cites W2601170132 @default.
- W2883170783 cites W2756469595 @default.
- W2883170783 cites W2768295325 @default.
- W2883170783 cites W2769200889 @default.
- W2883170783 cites W2786522203 @default.
- W2883170783 cites W4244538980 @default.
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- W2883170783 doi "https://doi.org/10.1002/pi.5680" @default.
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