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- W2883177217 endingPage "e1007500" @default.
- W2883177217 startingPage "e1007500" @default.
- W2883177217 abstract "Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circadian behaviour by misexpressing it within circadian clock cells. Manipulation of miR-210 expression levels in the PDF (pigment dispersing factor) positive neurons affected the phase of locomotor activity, under both light-dark conditions and constant darkness. PER cyclical expression was not affected in clock neurons, however, when miR-210 was up-regulated, a dramatic alteration in the morphology of PDF ventral lateral neuron (LNv) arborisations was observed. The effect of miR-210 in shaping neuronal projections was confirmed in vitro, using a Drosophila neuronal cell line. A transcriptomic analysis revealed that miR-210 overexpression affects the expression of several genes belonging to pathways related to circadian processes, neuronal development, GTPases signal transduction and photoreception. Collectively, these data reveal the role of miR-210 in modulating circadian outputs in flies and guiding/remodelling PDF positive LNv arborisations and indicate that miR-210 may have pleiotropic effects on the clock, light perception and neuronal development." @default.
- W2883177217 created "2018-08-03" @default.
- W2883177217 creator A5008726955 @default.
- W2883177217 creator A5011252915 @default.
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- W2883177217 creator A5020316144 @default.
- W2883177217 creator A5024561891 @default.
- W2883177217 creator A5059244238 @default.
- W2883177217 creator A5090975976 @default.
- W2883177217 date "2018-07-16" @default.
- W2883177217 modified "2023-10-17" @default.
- W2883177217 title "Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster" @default.
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