FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883179112> ?p ?o ?g. }

• W2883179112 endingPage "109" @default.
• W2883179112 startingPage "98" @default.
• W2883179112 abstract "Objective Increasing evidence suggests that cerebellar damage impacts on cognitive functions. Frontotemporal dementias (FTDs) are neurodegenerative brain conditions, primarily affecting the frontal and/or temporal lobe. Three main phenotypes are recognized, each with a distinct clinical and cognitive profile: behavioral‐variant FTD (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The severity of cerebellar changes and their relation to cognition in FTD, however, remain unclear. This study aimed to establish cerebellar gray matter changes on magnetic resonance imaging (MRI) and their relation to profiles of cognitive deficits in FTD subtypes. Methods Ninety‐six FTD patients (45 bvFTD, 28 SD, and 23 PNFA), meeting current clinical diagnostic criteria, and 35 age‐, sex‐, and education‐matched controls underwent brain MRI and cognitive assessment. Cerebral and cerebellar gray matter integrity were investigated using voxel‐based morphometry. Results Compared with controls, widespread bilateral cerebellar changes were observed in all FTD subtypes, with the greatest atrophy present in bvFTD. Significant associations were found between cerebellar integrity and cognitive performance in attention and working memory in bvFTD, visuospatial function in SD, and language‐motor function in PNFA. Bilateral atrophy of crus and lobule VI were most commonly associated with cognitive deficits, irrespective of FTD phenotype. Interpretation This study is the first to identify distinct patterns of cerebellar atrophy across FTD syndromes, which in turn relate to discrete cognitive dysfunctions, after accounting for the effect of cerebral atrophy. These findings extend our understanding of the cerebellum and point to its involvement across an array of processes beyond the domain of motor function. Ann Neurol 2018;83:98–109" @default.
• W2883179112 created "2018-08-03" @default.
• W2883179112 creator A5009397419 @default.
• W2883179112 creator A5028780184 @default.
• W2883179112 creator A5054871768 @default.
• W2883179112 creator A5054956123 @default.
• W2883179112 creator A5069129362 @default.
• W2883179112 creator A5078941041 @default.
• W2883179112 date "2018-07-01" @default.
• W2883179112 modified "2023-09-25" @default.
• W2883179112 title "Cerebellar atrophy and its contribution to cognition in frontotemporal dementias" @default.
• W2883179112 cites W1570777051 @default.
• W2883179112 cites W1589968137 @default.
• W2883179112 cites W1896720209 @default.
• W2883179112 cites W1936067772 @default.
• W2883179112 cites W1964113540 @default.
• W2883179112 cites W1966848686 @default.
• W2883179112 cites W1977093186 @default.
• W2883179112 cites W1981056670 @default.
• W2883179112 cites W1981786093 @default.
• W2883179112 cites W1983182638 @default.
• W2883179112 cites W1986739789 @default.
• W2883179112 cites W1992220964 @default.
• W2883179112 cites W1999887188 @default.
• W2883179112 cites W2006096283 @default.
• W2883179112 cites W2010681077 @default.
• W2883179112 cites W2021422157 @default.
• W2883179112 cites W2036427176 @default.
• W2883179112 cites W2045151039 @default.
• W2883179112 cites W2051879624 @default.
• W2883179112 cites W2052001451 @default.
• W2883179112 cites W2067456724 @default.
• W2883179112 cites W2067669427 @default.
• W2883179112 cites W2071881327 @default.
• W2883179112 cites W2079590167 @default.
• W2883179112 cites W2081808793 @default.
• W2883179112 cites W2085027326 @default.
• W2883179112 cites W2093364842 @default.
• W2883179112 cites W2095798723 @default.
• W2883179112 cites W2098108064 @default.
• W2883179112 cites W2100623206 @default.
• W2883179112 cites W2104284834 @default.
• W2883179112 cites W2113576511 @default.
• W2883179112 cites W2114133705 @default.
• W2883179112 cites W2114452946 @default.
• W2883179112 cites W2115886810 @default.
• W2883179112 cites W2119848633 @default.
• W2883179112 cites W2128030851 @default.
• W2883179112 cites W2128595931 @default.
• W2883179112 cites W2136032818 @default.
• W2883179112 cites W2136573752 @default.
• W2883179112 cites W2137404280 @default.
• W2883179112 cites W2138190873 @default.
• W2883179112 cites W2138790588 @default.
• W2883179112 cites W2150523249 @default.
• W2883179112 cites W2150825673 @default.
• W2883179112 cites W2153810897 @default.
• W2883179112 cites W2154945114 @default.
• W2883179112 cites W2157981217 @default.
• W2883179112 cites W2168365826 @default.
• W2883179112 cites W2170754752 @default.
• W2883179112 cites W2262227503 @default.
• W2883179112 cites W2277194479 @default.
• W2883179112 cites W2282191832 @default.
• W2883179112 cites W2326410747 @default.
• W2883179112 cites W2326479909 @default.
• W2883179112 cites W2334692654 @default.
• W2883179112 cites W2416297839 @default.
• W2883179112 cites W2460399536 @default.
• W2883179112 cites W2478839967 @default.
• W2883179112 cites W2508198209 @default.
• W2883179112 cites W2528333400 @default.
• W2883179112 cites W2547424619 @default.
• W2883179112 cites W2561447722 @default.
• W2883179112 cites W2599402371 @default.
• W2883179112 cites W2612881983 @default.
• W2883179112 cites W2616644965 @default.
• W2883179112 cites W2740893736 @default.
• W2883179112 cites W2754224635 @default.
• W2883179112 cites W2760766496 @default.
• W2883179112 cites W2766970894 @default.
• W2883179112 cites W2768454508 @default.
• W2883179112 cites W2790936874 @default.
• W2883179112 cites W4230948622 @default.
• W2883179112 cites W4233994114 @default.
• W2883179112 doi "https://doi.org/10.1002/ana.25271" @default.
• W2883179112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30014499" @default.
• W2883179112 hasPublicationYear "2018" @default.
• W2883179112 type Work @default.
• W2883179112 sameAs 2883179112 @default.
• W2883179112 citedByCount "45" @default.
• W2883179112 countsByYear W28831791122018 @default.
• W2883179112 countsByYear W28831791122019 @default.
• W2883179112 countsByYear W28831791122020 @default.
• W2883179112 countsByYear W28831791122021 @default.
• W2883179112 countsByYear W28831791122022 @default.
• W2883179112 countsByYear W28831791122023 @default.
• W2883179112 crossrefType "journal-article" @default.

• next