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- W2883192783 abstract "In this work we present new scalable, information theory-based variational methods for the efficient model reduction of high-dimensional deterministic and stochastic reaction networks. The proposed methodology combines, (a) information theoretic tools for sensitivity analysis that allow us to identify the proper coarse variables of the reaction network, with (b) variational approximate inference methods for training a best-fit reduced model. This approach takes advantage of both physicochemical modeling and data-based approaches and allows to construct optimal parameterized reduced dynamics in the number of variables, reactions and parameters, while controlling the information loss due to the reduction. We demonstrate the effectiveness of our model reduction method on several complex, high-dimensional chemical reaction networks arising in biochemistry." @default.
- W2883192783 created "2018-08-03" @default.
- W2883192783 creator A5045079747 @default.
- W2883192783 creator A5059757671 @default.
- W2883192783 date "2018-07-14" @default.
- W2883192783 modified "2023-09-27" @default.
- W2883192783 title "Information-based Variational Model Reduction of high-dimensional Reaction Networks" @default.
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