FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883194082> ?p ?o ?g. }

• W2883194082 endingPage "e0200697" @default.
• W2883194082 startingPage "e0200697" @default.
• W2883194082 abstract "The purpose of this study was to determine whether blocking of G protein βγ (Gβγ) signaling halts heart failure (HF) progression by macrophage phenotype manipulation. Cardiac Gβγ signaling plays a crucial role in HF pathogenesis. Previous data suggested that inhibiting Gβγ signaling reprograms T helper cell 1 (Th1) and Th2 cytokines, suggesting that Gβγ might be a useful drug target for treating HF. We investigated the efficacy of a small molecule Gβγ inhibitor, gallein, in a clinically relevant, experimental autoimmune myocarditis (EAM) model of HF as well as in human macrophage phenotypes in vitro. In the myocardium of HF patients, we observed that G protein coupled receptor kinase (GRK)2 levels were down-regulated compared with healthy controls. In rat EAM, treatment with gallein effectively improved survival and cardiac function, suppressed cardiac remodeling, and further attenuated myocardial protein expression of GRK2 as well as high mobility group box (HMGB)1 and its cascade signaling proteins. Furthermore, gallein effectively inhibited M1 polarization and promoted M2 polarization in vivo in the EAM heart and in vitro in human monocyte-derived macrophages. Taken together, these data suggest that the small molecule Gβγ inhibitor, gallein, could be an important pharmacologic therapy for HF as it can switch the phenotypic reprogramming from M1 to M2 phenotype in a rat model of EAM heart and in human macrophages." @default.
• W2883194082 created "2018-08-03" @default.
• W2883194082 creator A5000260621 @default.
• W2883194082 creator A5001792309 @default.
• W2883194082 creator A5006608675 @default.
• W2883194082 creator A5010306724 @default.
• W2883194082 creator A5015999831 @default.
• W2883194082 creator A5023350614 @default.
• W2883194082 creator A5025055108 @default.
• W2883194082 creator A5026451538 @default.
• W2883194082 creator A5030078373 @default.
• W2883194082 creator A5031679402 @default.
• W2883194082 creator A5038457825 @default.
• W2883194082 creator A5058022497 @default.
• W2883194082 creator A5068445895 @default.
• W2883194082 creator A5082897642 @default.
• W2883194082 creator A5091688084 @default.
• W2883194082 date "2018-07-19" @default.
• W2883194082 modified "2023-10-14" @default.
• W2883194082 title "Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats" @default.
• W2883194082 cites W1993816405 @default.
• W2883194082 cites W2017234408 @default.
• W2883194082 cites W2022338473 @default.
• W2883194082 cites W2023516334 @default.
• W2883194082 cites W2024648093 @default.
• W2883194082 cites W2047882967 @default.
• W2883194082 cites W2066221339 @default.
• W2883194082 cites W2076776759 @default.
• W2883194082 cites W2085701716 @default.
• W2883194082 cites W2092405677 @default.
• W2883194082 cites W2093452628 @default.
• W2883194082 cites W2102587224 @default.
• W2883194082 cites W2118579624 @default.
• W2883194082 cites W2118638261 @default.
• W2883194082 cites W2118960089 @default.
• W2883194082 cites W2122141298 @default.
• W2883194082 cites W2138625702 @default.
• W2883194082 cites W2140675350 @default.
• W2883194082 cites W2145335113 @default.
• W2883194082 cites W2148878078 @default.
• W2883194082 cites W2149869796 @default.
• W2883194082 cites W2155007822 @default.
• W2883194082 cites W2166137616 @default.
• W2883194082 cites W2191557497 @default.
• W2883194082 cites W2283472952 @default.
• W2883194082 cites W2303638538 @default.
• W2883194082 cites W2321660492 @default.
• W2883194082 cites W2337729778 @default.
• W2883194082 cites W2337933193 @default.
• W2883194082 cites W2339577610 @default.
• W2883194082 cites W2366525140 @default.
• W2883194082 cites W2589417015 @default.
• W2883194082 cites W295353521 @default.
• W2883194082 doi "https://doi.org/10.1371/journal.pone.0200697" @default.
• W2883194082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6053176" @default.
• W2883194082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30024944" @default.
• W2883194082 hasPublicationYear "2018" @default.
• W2883194082 type Work @default.
• W2883194082 sameAs 2883194082 @default.
• W2883194082 citedByCount "11" @default.
• W2883194082 countsByYear W28831940822019 @default.
• W2883194082 countsByYear W28831940822021 @default.
• W2883194082 countsByYear W28831940822022 @default.
• W2883194082 countsByYear W28831940822023 @default.
• W2883194082 crossrefType "journal-article" @default.
• W2883194082 hasAuthorship W2883194082A5000260621 @default.
• W2883194082 hasAuthorship W2883194082A5001792309 @default.
• W2883194082 hasAuthorship W2883194082A5006608675 @default.
• W2883194082 hasAuthorship W2883194082A5010306724 @default.
• W2883194082 hasAuthorship W2883194082A5015999831 @default.
• W2883194082 hasAuthorship W2883194082A5023350614 @default.
• W2883194082 hasAuthorship W2883194082A5025055108 @default.
• W2883194082 hasAuthorship W2883194082A5026451538 @default.
• W2883194082 hasAuthorship W2883194082A5030078373 @default.
• W2883194082 hasAuthorship W2883194082A5031679402 @default.
• W2883194082 hasAuthorship W2883194082A5038457825 @default.
• W2883194082 hasAuthorship W2883194082A5058022497 @default.
• W2883194082 hasAuthorship W2883194082A5068445895 @default.
• W2883194082 hasAuthorship W2883194082A5082897642 @default.
• W2883194082 hasAuthorship W2883194082A5091688084 @default.
• W2883194082 hasBestOaLocation W28831940821 @default.
• W2883194082 hasConcept C104317684 @default.
• W2883194082 hasConcept C126322002 @default.
• W2883194082 hasConcept C127716648 @default.
• W2883194082 hasConcept C170493617 @default.
• W2883194082 hasConcept C184235292 @default.
• W2883194082 hasConcept C202751555 @default.
• W2883194082 hasConcept C203014093 @default.
• W2883194082 hasConcept C2776682551 @default.
• W2883194082 hasConcept C2778198053 @default.
• W2883194082 hasConcept C2779244956 @default.
• W2883194082 hasConcept C2779537366 @default.
• W2883194082 hasConcept C2780875844 @default.
• W2883194082 hasConcept C2781184567 @default.
• W2883194082 hasConcept C502942594 @default.
• W2883194082 hasConcept C55493867 @default.
• W2883194082 hasConcept C62478195 @default.
• W2883194082 hasConcept C71924100 @default.

• next