Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883197899> ?p ?o ?g. }
- W2883197899 endingPage "852" @default.
- W2883197899 startingPage "845" @default.
- W2883197899 abstract "Postmenopausal depression has been shown to be related to the reduction of ovarian hormones produced as a woman transitions from a menopausal to a post-menopausal stage. What remains to be known is which type of estrogen receptor plays a key role in estrogen neuroprotection, a process that may be mediated by potentiating brain mitochondrial function and inhibiting mitochondria-associated apoptosis. In order to better imitate the condition of postmenopause, we conducted our research on aged female rats. Plasma estrogen levels declined significantly in ovariectomized rats and 16-month-old female rats, while anxiety and depression-like behavior increase. Moreover, ERα, ERβ, GPER, Bcl2 and UCP2 expression decreased significantly in hippocampus in female rats following ovariectomy. In our study, the anxiety and depression-like behavior in aged female rats were significantly relieved after the treatment of G-1, the GPER agonist. Furthermore, G-1 could reverse the reduction of ERα, ERβ, GPER, Bcl2 and UCP2 expression within the hippocampus. Mitochondrial JC-1 staining indicated that mitochondrial membrane potential increased after G-1 treatment. In addition, total antioxidant capacity (TAC) and superoxide dismutase activity (SOD) were found to be elevated in aged female rats following G-1 treatment. Taken together, estrogen receptors, especially GPER, may activate anti-apoptotic signaling and accelerate mitochondrial function. Therefore, GPER could be the potential therapeutic target for estrogen deficiency-related affective disorders." @default.
- W2883197899 created "2018-08-03" @default.
- W2883197899 creator A5020478356 @default.
- W2883197899 creator A5036101957 @default.
- W2883197899 creator A5038107949 @default.
- W2883197899 creator A5040509391 @default.
- W2883197899 creator A5057903251 @default.
- W2883197899 creator A5062281397 @default.
- W2883197899 creator A5064307868 @default.
- W2883197899 creator A5067328336 @default.
- W2883197899 creator A5069168079 @default.
- W2883197899 creator A5070959241 @default.
- W2883197899 date "2019-02-01" @default.
- W2883197899 modified "2023-10-14" @default.
- W2883197899 title "G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats" @default.
- W2883197899 cites W1586699954 @default.
- W2883197899 cites W1606732951 @default.
- W2883197899 cites W1840302677 @default.
- W2883197899 cites W1967939597 @default.
- W2883197899 cites W1972086601 @default.
- W2883197899 cites W1972211929 @default.
- W2883197899 cites W1979986181 @default.
- W2883197899 cites W1981467972 @default.
- W2883197899 cites W1988091814 @default.
- W2883197899 cites W1988900379 @default.
- W2883197899 cites W1999766015 @default.
- W2883197899 cites W2002627834 @default.
- W2883197899 cites W2005147324 @default.
- W2883197899 cites W2005356261 @default.
- W2883197899 cites W2010166612 @default.
- W2883197899 cites W2012080584 @default.
- W2883197899 cites W2019443766 @default.
- W2883197899 cites W2022107732 @default.
- W2883197899 cites W2026198636 @default.
- W2883197899 cites W2028503497 @default.
- W2883197899 cites W2029194434 @default.
- W2883197899 cites W2030313584 @default.
- W2883197899 cites W2030997633 @default.
- W2883197899 cites W2034471064 @default.
- W2883197899 cites W2034668210 @default.
- W2883197899 cites W2037611373 @default.
- W2883197899 cites W2037790468 @default.
- W2883197899 cites W2039256946 @default.
- W2883197899 cites W2039999459 @default.
- W2883197899 cites W2045045840 @default.
- W2883197899 cites W2045309695 @default.
- W2883197899 cites W2046082610 @default.
- W2883197899 cites W2053673554 @default.
- W2883197899 cites W2055333010 @default.
- W2883197899 cites W2060006903 @default.
- W2883197899 cites W2064984806 @default.
- W2883197899 cites W2070371854 @default.
- W2883197899 cites W2080544322 @default.
- W2883197899 cites W2083031515 @default.
- W2883197899 cites W2086974237 @default.
- W2883197899 cites W2087034766 @default.
- W2883197899 cites W2089662895 @default.
- W2883197899 cites W2094200895 @default.
- W2883197899 cites W2096665423 @default.
- W2883197899 cites W2099901435 @default.
- W2883197899 cites W2103019385 @default.
- W2883197899 cites W2105406570 @default.
- W2883197899 cites W2106077706 @default.
- W2883197899 cites W2110370409 @default.
- W2883197899 cites W2110808599 @default.
- W2883197899 cites W2111523997 @default.
- W2883197899 cites W2123624041 @default.
- W2883197899 cites W2123652060 @default.
- W2883197899 cites W2125000296 @default.
- W2883197899 cites W2140002693 @default.
- W2883197899 cites W2140179339 @default.
- W2883197899 cites W2143152245 @default.
- W2883197899 cites W2143176261 @default.
- W2883197899 cites W2144657436 @default.
- W2883197899 cites W2151358022 @default.
- W2883197899 cites W2151524159 @default.
- W2883197899 cites W2152754523 @default.
- W2883197899 cites W2153157873 @default.
- W2883197899 cites W2153895029 @default.
- W2883197899 cites W2161695527 @default.
- W2883197899 cites W2164804511 @default.
- W2883197899 cites W2167093282 @default.
- W2883197899 cites W2179306922 @default.
- W2883197899 cites W2203314189 @default.
- W2883197899 cites W2269850420 @default.
- W2883197899 cites W2297235619 @default.
- W2883197899 cites W2307104826 @default.
- W2883197899 cites W2316944130 @default.
- W2883197899 cites W2402023904 @default.
- W2883197899 cites W2427540278 @default.
- W2883197899 cites W2429813790 @default.
- W2883197899 cites W2476538392 @default.
- W2883197899 cites W2519422916 @default.
- W2883197899 doi "https://doi.org/10.1016/j.bbr.2018.07.017" @default.
- W2883197899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30041006" @default.
- W2883197899 hasPublicationYear "2019" @default.
- W2883197899 type Work @default.
- W2883197899 sameAs 2883197899 @default.