Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883208737> ?p ?o ?g. }
- W2883208737 endingPage "30" @default.
- W2883208737 startingPage "19" @default.
- W2883208737 abstract "Whether cardiac output in decapod crustaceans is under circadian control has long been debated, with mixed evidence for and against the hypothesis. Moreover, the locus of the clock system controlling cardiac activity, if it is under circadian control, is unknown. However, a report that the crayfish heart in organ culture maintains a circadian oscillation in heartbeat frequency suggests the presence of a peripheral pacemaker within the cardiac neuromuscular system itself. Because the decapod heart is neurogenic, with contractions controlled by the five motor and four premotor neurons that make up the cardiac ganglion (CG), a likely locus for a circadian clock is the CG itself. Here, a CG-specific transcriptome was generated for the lobster, Homarus americanus, and was used to assess the presence/absence of transcripts encoding putative clock-related proteins in the ganglion. Using known Homarus brain/eyestalk ganglia clock-related proteins as queries, BLAST searches of the CG transcriptome were conducted for the five proteins that form the core clock, i.e., clock, cryptochrome 2, cycle, period and timeless, as well as for a variety of clock-associated, clock input pathway and clock output pathway proteins. With the exception of pigment dispersing hormone receptor [PDHR], a putative clock output pathway protein, one or more transcripts encoding each of the proteins searched for were identified from the CG assembly; no PDHR-encoding transcripts were found. RT-PCR confirmed the expression of all core clock transcripts in multiple independent CG cDNAs; RNA-Seq data suggest that both the motor and premotor neurons could contribute to the cellular locus of a pacemaker. These data provide support for the possible existence of an intrinsic circadian clock in the H. americanus CG, and form a foundation for guiding future anatomical, molecular and physiological investigations of circadian signaling in the lobster cardiac neuromuscular system." @default.
- W2883208737 created "2018-08-03" @default.
- W2883208737 creator A5010287880 @default.
- W2883208737 creator A5028103712 @default.
- W2883208737 creator A5052986958 @default.
- W2883208737 creator A5057881385 @default.
- W2883208737 creator A5058453821 @default.
- W2883208737 creator A5065252723 @default.
- W2883208737 creator A5065324847 @default.
- W2883208737 creator A5068678816 @default.
- W2883208737 creator A5068740456 @default.
- W2883208737 creator A5078404222 @default.
- W2883208737 date "2018-10-01" @default.
- W2883208737 modified "2023-10-12" @default.
- W2883208737 title "Molecular evidence for an intrinsic circadian pacemaker in the cardiac ganglion of the American lobster, Homarus americanus - Is diel cycling of heartbeat frequency controlled by a peripheral clock system?" @default.
- W2883208737 cites W1527313768 @default.
- W2883208737 cites W1971566736 @default.
- W2883208737 cites W1986954581 @default.
- W2883208737 cites W1986959361 @default.
- W2883208737 cites W1997213971 @default.
- W2883208737 cites W2007230114 @default.
- W2883208737 cites W2011657487 @default.
- W2883208737 cites W2020898077 @default.
- W2883208737 cites W2021691421 @default.
- W2883208737 cites W2026223354 @default.
- W2883208737 cites W2044777835 @default.
- W2883208737 cites W2049791793 @default.
- W2883208737 cites W2052965191 @default.
- W2883208737 cites W2054179107 @default.
- W2883208737 cites W2062009344 @default.
- W2883208737 cites W2062942415 @default.
- W2883208737 cites W2064190998 @default.
- W2883208737 cites W2075932078 @default.
- W2883208737 cites W2077769816 @default.
- W2883208737 cites W2079711090 @default.
- W2883208737 cites W2081361979 @default.
- W2883208737 cites W2114104545 @default.
- W2883208737 cites W2116774196 @default.
- W2883208737 cites W2124985265 @default.
- W2883208737 cites W2126419817 @default.
- W2883208737 cites W2128880918 @default.
- W2883208737 cites W2129187867 @default.
- W2883208737 cites W2139819456 @default.
- W2883208737 cites W2145517507 @default.
- W2883208737 cites W2154431984 @default.
- W2883208737 cites W2155981340 @default.
- W2883208737 cites W2158799586 @default.
- W2883208737 cites W2160378127 @default.
- W2883208737 cites W2164824098 @default.
- W2883208737 cites W2173492011 @default.
- W2883208737 cites W2224056471 @default.
- W2883208737 cites W2273682835 @default.
- W2883208737 cites W2323326409 @default.
- W2883208737 cites W2545753590 @default.
- W2883208737 cites W2546658907 @default.
- W2883208737 cites W2757824988 @default.
- W2883208737 cites W2767171607 @default.
- W2883208737 cites W2797320012 @default.
- W2883208737 cites W2963629592 @default.
- W2883208737 doi "https://doi.org/10.1016/j.margen.2018.07.001" @default.
- W2883208737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30031746" @default.
- W2883208737 hasPublicationYear "2018" @default.
- W2883208737 type Work @default.
- W2883208737 sameAs 2883208737 @default.
- W2883208737 citedByCount "17" @default.
- W2883208737 countsByYear W28832087372018 @default.
- W2883208737 countsByYear W28832087372019 @default.
- W2883208737 countsByYear W28832087372020 @default.
- W2883208737 countsByYear W28832087372021 @default.
- W2883208737 countsByYear W28832087372022 @default.
- W2883208737 crossrefType "journal-article" @default.
- W2883208737 hasAuthorship W2883208737A5010287880 @default.
- W2883208737 hasAuthorship W2883208737A5028103712 @default.
- W2883208737 hasAuthorship W2883208737A5052986958 @default.
- W2883208737 hasAuthorship W2883208737A5057881385 @default.
- W2883208737 hasAuthorship W2883208737A5058453821 @default.
- W2883208737 hasAuthorship W2883208737A5065252723 @default.
- W2883208737 hasAuthorship W2883208737A5065324847 @default.
- W2883208737 hasAuthorship W2883208737A5068678816 @default.
- W2883208737 hasAuthorship W2883208737A5068740456 @default.
- W2883208737 hasAuthorship W2883208737A5078404222 @default.
- W2883208737 hasBestOaLocation W28832087371 @default.
- W2883208737 hasConcept C121446783 @default.
- W2883208737 hasConcept C126322002 @default.
- W2883208737 hasConcept C169760540 @default.
- W2883208737 hasConcept C184738001 @default.
- W2883208737 hasConcept C18903297 @default.
- W2883208737 hasConcept C2780118809 @default.
- W2883208737 hasConcept C38606739 @default.
- W2883208737 hasConcept C71924100 @default.
- W2883208737 hasConcept C84766238 @default.
- W2883208737 hasConcept C86803240 @default.
- W2883208737 hasConcept C95444343 @default.
- W2883208737 hasConceptScore W2883208737C121446783 @default.
- W2883208737 hasConceptScore W2883208737C126322002 @default.
- W2883208737 hasConceptScore W2883208737C169760540 @default.
- W2883208737 hasConceptScore W2883208737C184738001 @default.
- W2883208737 hasConceptScore W2883208737C18903297 @default.