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• W2883216123 abstract "Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokinetic analyses. Respective median areas under the concentration-time curve from 0 to 24 h (AUC0-24) were 109.49, 97.86, 145.33, and 207.04 μg · h/ml. Median maximum plasma concentration (Cmax) were 11.90, 12.02, 14.86, and 19.17 μg/ml, respectively. Higher levofloxacin doses, up to 1,500 mg daily, resulted in higher exposures. (This study has been registered at ClinicalTrials.gov under identifier NCT01918397.)." @default.
• W2883216123 created "2018-08-03" @default.
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• W2883216123 date "2018-10-01" @default.
• W2883216123 modified "2023-10-17" @default.
• W2883216123 title "Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis" @default.
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• W2883216123 doi "https://doi.org/10.1128/aac.00770-18" @default.
• W2883216123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6153781" @default.
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