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- W2883258987 endingPage "1605" @default.
- W2883258987 startingPage "1594" @default.
- W2883258987 abstract "Asthma is a common disease in childhood with a minority of affected children having severe therapy-resistant asthma (STRA). Children with STRA can be differentiated from those with mild-moderate disease by greater allergic sensitization, increased eosinophilic airway inflammation, increased airway remodelling and reduced corticosteroid responsiveness. The aetiology of STRA in children is multifactorial but allergy seems to play a key role. Many children with asthma have coexisting allergic disease, and severe rhinitis seems to be an important driver of STRA in children. Allergies to foods, moulds, pollen and pets have also been associated with severe asthma exacerbations. Identifying allergens that are driving asthma symptoms in children with STRA may provide additional strategies for improving their disease control. Avoidance strategies may be possible. Additional monoclonal antibody therapy with Omalizumab or Mepolizumab may be helpful in children with clinically important polysensitization." @default.
- W2883258987 created "2018-08-03" @default.
- W2883258987 creator A5065281895 @default.
- W2883258987 creator A5073642254 @default.
- W2883258987 date "2018-10-12" @default.
- W2883258987 modified "2023-10-14" @default.
- W2883258987 title "Does allergy explain why some children have severe asthma?" @default.
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