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- W2883260400 abstract "Background and Aims: Living donor liver transplantation carries small but real risk to live donor. Donor steatosis, fibrosis and NASH in donor are common cause of rejection in Living donor liver transplantation. Hereby we report our experience of LDLT in donors with NASH and fibrosis. Methods: 394 patients underwent living donor liver transplantation from August 2011 to January 2018. Liver steatosis was seen in 47 patients. All these patients underwent donor optimization protocol, involving dietary modification, exercise regimen and targeted weight reduction. Results: Of the 47 patients with liver steatosis, 8 patients had NASH and fibrosis. After lifestyle change, dietary modification and exercise regimens, repeat biopsies were done in 6 patients. All 6 patients showed resolution of NASH and fibrosis. 5 donors underwent right hepatectomies and 1 underwent left hepatectomy. 2 patients did not undergo liver biopsy, they underwent emergency left lobectomy and left lateral sectionectomy for ALF. No donor had post hepatectomy liver failure (50-50 criteria). 2 patients had grade 3a complications needing PCD for pleural effusion. Analyzing the recipient outcomes, 1 patient had mortality (not related to graft function). Conclusions: NASH and fibrosis can be reversed with carefully selected motivated donors, with lifestyle modification, diet and exercise planning. This increases the donor pool for living donor liver transplantation. The authors have none to declare." @default.
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- W2883260400 date "2018-07-01" @default.
- W2883260400 modified "2023-10-11" @default.
- W2883260400 title "12. Expanding the donor pool for living donor liver transplantation: experience with nash and fibrosis" @default.
- W2883260400 doi "https://doi.org/10.1016/j.jceh.2018.06.438" @default.
- W2883260400 hasPublicationYear "2018" @default.
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