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• W2883287112 endingPage "2972" @default.
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• W2883287112 abstract "Abstract Ocular dominance (OD) plasticity has been extensively studied in various mammalian species. While robust OD shifts are typically observed after monocular eyelid suture, relatively poor OD plasticity is observed for early eye removal or after tetrodotoxin (TTX) injections in mice. Hence, abnormal binocular signal interactions in the visual cortex may play a critical role in eliciting OD plasticity. Here, we examined the histochemical changes in the lateral geniculate nucleus (LGN) and the striate cortex (V1) in macaque monkeys that experienced two different monocular sensory deprivations in the same eye beginning at 3 weeks of age: restricted laser lesions in macular or peripheral retina and form deprivation induced by wearing a diffuser lens during the critical period. The monkeys were subsequently reared for 5 years under a normal visual environment. In the LGN, atrophy of neurons and a dramatic increase of GFAP expression were observed in the lesion projection zones (LPZs). In V1, although no obvious shift of the LPZ border was found, the ocular dominance columns (ODCs) for the lesioned eye shrunk and those for the intact eye expanded over the entirety of V1. This ODC size change was larger in the area outside the LPZ and in the region inside the LPZ near the border compared to that in the LPZ center. These developmental changes may reflect abnormal binocular interactions in V1 during early infancy. Our observations provide insights into the nature of degenerative and plastic changes in the LGN and V1 following early chronic monocular sensory deprivations." @default.
• W2883287112 created "2018-08-03" @default.
• W2883287112 creator A5024521566 @default.
• W2883287112 creator A5043373157 @default.
• W2883287112 creator A5044769585 @default.
• W2883287112 creator A5062874353 @default.
• W2883287112 creator A5053169566 @default.
• W2883287112 date "2018-11-14" @default.
• W2883287112 modified "2023-09-26" @default.
• W2883287112 title "Long-term histological changes in the macaque primary visual cortex and the lateral geniculate nucleus after monocular deprivation produced by early restricted retinal lesions and diffuser induced form deprivation" @default.
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• W2883287112 doi "https://doi.org/10.1002/cne.24494" @default.
• W2883287112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6283693" @default.
• W2883287112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30004587" @default.
• W2883287112 hasPublicationYear "2018" @default.
• W2883287112 type Work @default.
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