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- W2883313178 abstract "Regenerative medicine has been growing because of the emergent need for tissues/organs for transplants and restorative surgeries. Biological scaffolds are important tools to try to solve this problem. The one used in this reserach was developed by an acellular biological scaffold from canine placenta with a rich source of cellular matrix. After decellularization, the cellular matrix demonstrated structural preservation with the presence of important functional proteins such as collagen, fibronectin, and laminin. We used cells transduced with vascular endothelial growth factor (VEGF) to recellularize this scaffold. It was succeeded by seeding the cells in nonadherent plaques in the presence of the sterelized placenta scaffold. Cells were adhered to the scaffold when analyzed by immunocytochemistry and scanning electron microscopy, both showing sprouting of yolk sac VEGF (YSVEGF) cells. This recellularized scaffold is a promissory biomaterial for repairing injured areas where neovascularization is required." @default.
- W2883313178 created "2018-08-03" @default.
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- W2883313178 date "2018-07-01" @default.
- W2883313178 modified "2023-09-29" @default.
- W2883313178 title "Canine Placenta Recellularized Using Yolk Sac Cells with Vascular Endothelial Growth Factor" @default.
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- W2883313178 doi "https://doi.org/10.1089/biores.2018.0014" @default.
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