FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883315488> ?p ?o ?g. }

• W2883315488 abstract "Spermatogenesis is a tightly regulated process involving germ cell-specific and germ cell-predominant genes. Here we investigate a novel germ cell-specific gene, Spatc1l (spermatogenesis and centriole associated 1 like). Expression analyses show that SPATC1L is expressed in mouse and human testes. We find that mouse SPATC1L localizes to the neck region in testicular sperm. Moreover, SPATC1L associates with the regulatory subunit of protein kinase A (PKA). Using CRISPR/Cas9-mediated genome engineering, we generate mice lacking SPATC1L. Disruption of Spatc1l in mice leads to male sterility owing to separation of sperm heads from tails. The lack of SPATC1L is associated with a reduction in PKA activity in testicular sperm, and we identify capping protein muscle Z-line beta as a candidate target of phosphorylation by PKA in testis. Taken together, our results implicate the SPATC1L-PKA complex in maintaining the stability of the sperm head-tail junction, thereby revealing a new molecular basis for sperm head-tail integrity." @default.
• W2883315488 created "2018-08-03" @default.
• W2883315488 creator A5017188803 @default.
• W2883315488 creator A5033975141 @default.
• W2883315488 creator A5042266270 @default.
• W2883315488 creator A5043486744 @default.
• W2883315488 creator A5067379686 @default.
• W2883315488 creator A5075126907 @default.
• W2883315488 creator A5081221518 @default.
• W2883315488 creator A5082810437 @default.
• W2883315488 creator A5090050945 @default.
• W2883315488 creator A5090391516 @default.
• W2883315488 date "2018-07-19" @default.
• W2883315488 modified "2023-10-16" @default.
• W2883315488 title "<scp>SPATC</scp> 1L maintains the integrity of the sperm head‐tail junction" @default.
• W2883315488 cites W1510097228 @default.
• W2883315488 cites W1518196814 @default.
• W2883315488 cites W1964721684 @default.
• W2883315488 cites W1967600199 @default.
• W2883315488 cites W1968746042 @default.
• W2883315488 cites W1968807354 @default.
• W2883315488 cites W1970233133 @default.
• W2883315488 cites W1970870727 @default.
• W2883315488 cites W1977874001 @default.
• W2883315488 cites W1987216689 @default.
• W2883315488 cites W1990409602 @default.
• W2883315488 cites W1997481960 @default.
• W2883315488 cites W2004323314 @default.
• W2883315488 cites W2005209296 @default.
• W2883315488 cites W2007550555 @default.
• W2883315488 cites W2008123634 @default.
• W2883315488 cites W2012117158 @default.
• W2883315488 cites W2013137419 @default.
• W2883315488 cites W2013639515 @default.
• W2883315488 cites W2018847520 @default.
• W2883315488 cites W2023401782 @default.
• W2883315488 cites W2025755340 @default.
• W2883315488 cites W2027980594 @default.
• W2883315488 cites W2057911994 @default.
• W2883315488 cites W2058033084 @default.
• W2883315488 cites W2071740910 @default.
• W2883315488 cites W2080937125 @default.
• W2883315488 cites W2086560719 @default.
• W2883315488 cites W2087421398 @default.
• W2883315488 cites W2088408099 @default.
• W2883315488 cites W2097479331 @default.
• W2883315488 cites W2099224756 @default.
• W2883315488 cites W2102732162 @default.
• W2883315488 cites W2108696811 @default.
• W2883315488 cites W2110751401 @default.
• W2883315488 cites W2123749757 @default.
• W2883315488 cites W2127321420 @default.
• W2883315488 cites W2128116458 @default.
• W2883315488 cites W2128567669 @default.
• W2883315488 cites W2132800189 @default.
• W2883315488 cites W2140603377 @default.
• W2883315488 cites W2148824141 @default.
• W2883315488 cites W2149905790 @default.
• W2883315488 cites W2156339041 @default.
• W2883315488 cites W2157073932 @default.
• W2883315488 cites W2165544162 @default.
• W2883315488 cites W2171093797 @default.
• W2883315488 cites W2414416700 @default.
• W2883315488 cites W2518975446 @default.
• W2883315488 cites W2944835126 @default.
• W2883315488 cites W32035092 @default.
• W2883315488 cites W4322388712 @default.
• W2883315488 cites W77628998 @default.
• W2883315488 doi "https://doi.org/10.15252/embr.201845991" @default.
• W2883315488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6123647" @default.
• W2883315488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30026308" @default.
• W2883315488 hasPublicationYear "2018" @default.
• W2883315488 type Work @default.
• W2883315488 sameAs 2883315488 @default.
• W2883315488 citedByCount "28" @default.
• W2883315488 countsByYear W28833154882019 @default.
• W2883315488 countsByYear W28833154882020 @default.
• W2883315488 countsByYear W28833154882021 @default.
• W2883315488 countsByYear W28833154882022 @default.
• W2883315488 countsByYear W28833154882023 @default.
• W2883315488 crossrefType "journal-article" @default.
• W2883315488 hasAuthorship W2883315488A5017188803 @default.
• W2883315488 hasAuthorship W2883315488A5033975141 @default.
• W2883315488 hasAuthorship W2883315488A5042266270 @default.
• W2883315488 hasAuthorship W2883315488A5043486744 @default.
• W2883315488 hasAuthorship W2883315488A5067379686 @default.
• W2883315488 hasAuthorship W2883315488A5075126907 @default.
• W2883315488 hasAuthorship W2883315488A5081221518 @default.
• W2883315488 hasAuthorship W2883315488A5082810437 @default.
• W2883315488 hasAuthorship W2883315488A5090050945 @default.
• W2883315488 hasAuthorship W2883315488A5090391516 @default.
• W2883315488 hasBestOaLocation W28833154881 @default.
• W2883315488 hasConcept C104292427 @default.
• W2883315488 hasConcept C104317684 @default.
• W2883315488 hasConcept C109825262 @default.
• W2883315488 hasConcept C11960822 @default.
• W2883315488 hasConcept C123765429 @default.
• W2883315488 hasConcept C134018914 @default.
• W2883315488 hasConcept C20418707 @default.
• W2883315488 hasConcept C2779122487 @default.

• next