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• W2883324490 abstract "Developing vaccines that are safe, efficacious, and affordable for low-resource countries is complex and costly. There are challenges with glycoconjugate vaccines, particularly multivalent vaccines, due to their manufacturing complexity. Formulation development is one of the critical steps in developing a stable glycoconjugate vaccine and in order to be successful, a rational, designed approach is imperative. The approach must leverage current understanding around the critical quality attributes and cost drivers that are important for the product as well as the immunogenicity of the vaccine in clinical studies. With an emphasis on developing country vaccine manufacturers, this review describes formulation strategies and approaches to characterizing glycoconjugate vaccines using a broad analytical toolkit for development and transferring robust processes for production to developing country vaccine manufacturers." @default.
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• W2883324490 date "2018-01-01" @default.
• W2883324490 modified "2023-10-18" @default.
• W2883324490 title "Formulation Development of Glycoconjugate Vaccines for Low- and Middle-Income Countries" @default.
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• W2883324490 doi "https://doi.org/10.1021/bk-2018-1290.ch009" @default.
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